PDF(Pubmed)
Abstract：
Malignant tumors are the second most common cause of death worldwide. More attention is being paid to the link between the body\'s impaired oxidoreductive balance and cancer incidence. Much attention is being paid to polyphenols derived from plants, as one of their properties is an antioxidant character: the ability to eliminate reactive oxygen and nitrogen species, chelate specific metal ions, modulate signaling pathways affecting inflammation, and raise the level and activity of antioxidant enzymes while lowering those with oxidative effects. The following three compounds, resveratrol, quercetin, and curcumin, are polyphenols modulating multiple molecular targets, or increasing pro-apoptotic protein expression levels and decreasing anti-apoptotic protein expression levels. Experiments conducted in vitro and in vivo on animals and humans suggest using them as chemopreventive agents based on antioxidant properties. The advantage of these natural polyphenols is low toxicity and weak adverse effects at higher doses. However, the compounds discussed are characterized by low bioavailability and solubility, which may make achieving the blood concentrations needed for the desired effect challenging. The solution may lie in derivatives of naturally occurring polyphenols subjected to structural modifications that enhance their beneficial effects or work on implementing new ways of delivering antioxidants that improve their solubility and bioavailability.
摘要：
恶性肿瘤是全球第二大常见死亡原因。人们越来越关注人体氧化还原平衡受损与癌症发病率之间的联系。来自植物的多酚受到了很多关注，因为它们的特性之一是抗氧化特性：消除活性氧和氮的能力，螯合特定的金属离子，调节影响炎症的信号通路，并提高抗氧化酶的水平和活性，同时降低具有氧化作用的酶。以下三种化合物，白藜芦醇,槲皮素,还有姜黄素,是多酚调节多个分子靶标，或增加促凋亡蛋白表达水平和降低抗凋亡蛋白表达水平。在动物和人体内进行的体外和体内实验表明，基于抗氧化特性，将它们用作化学预防剂。这些天然多酚的优点是低毒性和较高剂量的弱副作用。然而,所讨论的化合物的特点是生物利用度和溶解度低，这可能使实现所需效果所需的血液浓度具有挑战性。该溶液可能存在于天然存在的多酚的衍生物中，这些衍生物经过了结构修饰，从而增强了它们的有益效果，或者致力于实现递送抗氧化剂的新方法，从而改善了它们的溶解度和生物利用度。
