Abstract：
BACKGROUND: Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC.
METHODS: Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial.
RESULTS: The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes.
CONCLUSIONS: The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.
METHODS: Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial.
RESULTS: The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes.
CONCLUSIONS: The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.
摘要：
背景：缺乏膳食铜摄入与胃癌（GC）之间潜在关联的证据。因此，我们的目的是在胃癌汇集(StomachcancerPooling,StomachcancerPooling,StomachcancerPooling,StoP,Project,一个GC流行病学研究的国际联盟内,评估这种关联.
方法：纳入了来自StoP项目中五个病例对照研究的数据（2448例，4350控件)。我们使用多变量混合效应逻辑回归模型估计了膳食铜摄入量与GC之间关联的校正比值比(OR)和95%CI。我们还使用分数多项式的逻辑混合效应模型对铜摄入量和GC之间的剂量反应关系进行了建模。
结果：铜摄入量最高四分位数与最低四分位数相比的OR为0.78（95％CI：0.63-0.95；趋势P=0.013）。非贲门型的结果相似(OR:0.72;95%CI:0.57-0.91),肠型（OR：0.75;95％CI：0.56-0.99）和其他组织学型GC（OR：0.65;95％CI：0.44-0.96）。剂量反应分析显示，适度摄入（<1毫克/天）的ORs急剧下降，随后在≤3mg/天（OR：0.09；95％CI：0.02-0.41）下保持稳定，并在较高摄入量下缓慢增加。
结论：我们的大型研究结果表明，铜摄入量可能与GC呈负相关，尽管他们需要前瞻性研究的确认。
方法：纳入了来自StoP项目中五个病例对照研究的数据（2448例，4350控件)。我们使用多变量混合效应逻辑回归模型估计了膳食铜摄入量与GC之间关联的校正比值比(OR)和95%CI。我们还使用分数多项式的逻辑混合效应模型对铜摄入量和GC之间的剂量反应关系进行了建模。
结果：铜摄入量最高四分位数与最低四分位数相比的OR为0.78（95％CI：0.63-0.95；趋势P=0.013）。非贲门型的结果相似(OR:0.72;95%CI:0.57-0.91),肠型（OR：0.75;95％CI：0.56-0.99）和其他组织学型GC（OR：0.65;95％CI：0.44-0.96）。剂量反应分析显示，适度摄入（<1毫克/天）的ORs急剧下降，随后在≤3mg/天（OR：0.09；95％CI：0.02-0.41）下保持稳定，并在较高摄入量下缓慢增加。
结论：我们的大型研究结果表明，铜摄入量可能与GC呈负相关，尽管他们需要前瞻性研究的确认。
