{Reference Type}: Journal Article
{Title}: Dietary intake of copper and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.
{Author}: Sassano M;Collatuzzo G;Seyyedsalehi MS;Pelucchi C;Bonzi R;Palli D;Ferraroni M;Lunet N;Morais S;López-Carrillo L;Malekzadeh R;Pakseresht M;López-Cervantes M;Ward MH;Camargo MC;Curado MP;Vioque J;Zhang ZF;Boccia S;Negri E;La Vecchia C;Boffetta P;
{Journal}: Int J Epidemiol
{Volume}: 53
{Issue}: 3
{Year}: 2024 Apr 11
{Factor}: 9.685
{DOI}: 10.1093/ije/dyae059
{Abstract}: <B>BACKGROUND: </B>Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC.<BR><B>METHODS: </B>Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial.<BR><B>RESULTS: </B>The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes.<BR><B>CONCLUSIONS: </B>The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.