%0 Journal Article
%T Dietary intake of copper and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.
%A Sassano M
%A Collatuzzo G
%A Seyyedsalehi MS
%A Pelucchi C
%A Bonzi R
%A Palli D
%A Ferraroni M
%A Lunet N
%A Morais S
%A López-Carrillo L
%A Malekzadeh R
%A Pakseresht M
%A López-Cervantes M
%A Ward MH
%A Camargo MC
%A Curado MP
%A Vioque J
%A Zhang ZF
%A Boccia S
%A Negri E
%A La Vecchia C
%A Boffetta P
%J Int J Epidemiol
%V 53
%N 3
%D 2024 Apr 11
%M 38670544
%F 9.685
%R 10.1093/ije/dyae059
%X <B>BACKGROUND: </B>Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC.<BR><B>METHODS: </B>Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial.<BR><B>RESULTS: </B>The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes.<BR><B>CONCLUSIONS: </B>The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.