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Abstract：
The purpose of this study is to investigate the serum inflammatory factors in patients with high-altitude polycythemia (HAPC) and their correlation with cognitive function. The subjects were recruited and placed into a HAPC group and control group. Serum samples were collected, and inflammatory factors (interleukin-1beta [IL-1β], monocyte chemoattractant protein-1 [MCP-1], and tumor necrosis factor-alpha [TNF-α]) were measured using ELISA kits. The mini-mental State Examination (MMSE) was used to assess cognitive function. According to the MMSE scores, HAPC group was further divided into normal cognitive function group (HNCF) and cognitive dysfunction group (HCDF). In comparison with the control group, the MMSE scores in the HAPC group were significantly low (P < .05), whereas the serum levels of IL-1β, MCP-1, and TNF-α were significantly high (P < .01). Among the HAPC group (n = 60), 21 belonged to the HCDF and 39 belonged to the HNCF. Compared with the HNCF, the IL-1β, MCP-1, and TNF-α in the HCDF were significantly increased (P < .01). The Pearson correlation analysis showed that inflammatory factors were positively correlated with hemoglobin, and negatively correlated with MMSE. Serum inflammatory cytokines IL-1, MCP-1, and TNF-α were increased in HAPC, and HAPC exhibited cognitive dysfunction. Considering chronic hypoxia environment influences the change of the red blood cell metabolic and inflammatory factor, red blood cells and inflammatory factor in plateau is likely to be affected by patients with vascular lesions, increase cognitive impairment.
摘要：
目的探讨高原红细胞增多症(HAPC)患者血清炎症因子水平及其与认知功能的相关性。招募受试者并将其置于HAPC组和对照组中。收集血清样本，和炎症因子(白细胞介素-1β[IL-1β]，单核细胞趋化蛋白-1[MCP-1]，和肿瘤坏死因子-α[TNF-α]）使用ELISA试剂盒进行测量。使用简易精神状态检查（MMSE）评估认知功能。根据MMSE评分,HAPC组又分为认知功能正常组(HNCF)和认知功能障碍组(HCDF)。与对照组相比，HAPC组的MMSE评分明显较低（P<0.05），而血清IL-1β水平，MCP-1和TNF-α显著升高(P<0.01)。在HAPC组（n=60）中，21属于HCDF，39属于HNCF。与HNCF相比，IL-1β，HCDF中MCP-1和TNF-α显著升高(P<0.01)。Pearson相关分析显示炎症因子与血红蛋白呈正相关,与MMSE呈负相关。血清炎症因子IL-1、MCP-1和TNF-α在HAPC中升高,和HAPC表现出认知功能障碍。考虑到慢性低氧环境对红细胞代谢及炎性因子变化的影响,高原红细胞和炎症因子可能受到血管病变患者的影响,增加认知障碍。
