PDF(Pubmed)
Abstract：
The incidence of invasive fungal diseases (IFDs) is on the rise globally, particularly among immunocompromised patients, leading to significant morbidity and mortality. Current clinical antifungal agents, such as polyenes, azoles, and echinocandins, face increasing resistance from pathogenic fungi. Therefore, there is a pressing need for the development of novel antifungal drugs. Marine-derived secondary metabolites represent valuable resources that are characterized by varied chemical structures and pharmacological activities. While numerous compounds exhibiting promising antifungal activity have been identified, a comprehensive review elucidating their specific underlying mechanisms remains lacking. In this review, we have compiled a summary of antifungal compounds derived from marine organisms, highlighting their diverse mechanisms of action targeting various fungal cellular components, including the cell wall, cell membrane, mitochondria, chromosomes, drug efflux pumps, and several biological processes, including vesicular trafficking and the growth of hyphae and biofilms. This review is helpful for the subsequent development of antifungal drugs due to its summary of the antifungal mechanisms of secondary metabolites from marine organisms.
摘要：
侵袭性真菌病（IFDs）的发病率在全球范围内呈上升趋势，特别是在免疫功能低下的患者中，导致显著的发病率和死亡率。目前临床抗真菌药物，比如多烯，唑类,和棘白菌素,面对病原真菌越来越多的耐药性。因此,迫切需要开发新的抗真菌药物。海洋衍生的次级代谢产物代表了具有不同化学结构和药理活性特征的宝贵资源。虽然已经鉴定了许多具有有希望的抗真菌活性的化合物，仍然缺乏全面审查，阐明其具体的基本机制。在这次审查中,我们已经汇编了来自海洋生物的抗真菌化合物的摘要，突出了它们针对各种真菌细胞成分的不同作用机制，包括细胞壁,细胞膜，线粒体,染色体,药物外排泵,和几个生物过程，包括囊泡运输和菌丝和生物膜的生长。本文综述了海洋生物次生代谢产物的抗真菌作用机制,为后续抗真菌药物的开发提供了参考。
