PDF(Pubmed)
Abstract：
Recent evidence has revealed associations between endocrine-disrupting chemicals (EDCs) and placental insufficiency due to altered placental growth, syncytialization, and trophoblast invasion. However, no epidemiologic study has reported associations between exposure to EDCs and asymmetric fetal growth restriction (FGR) caused by placenta insufficiency. The aim of this study was to evaluate the association between EDC exposure and asymmetric FGR. This was a prospective cohort study including women admitted for delivery to the Maternal Fetal Center at Seoul St. Mary\'s Hospital between October 2021 and October 2022. Maternal urine and cord blood samples were collected, and the levels of bisphenol-A (BPA), monoethyl phthalates, and perfluorooctanoic acid in each specimen were analyzed. We investigated linear and non-linear associations between the levels of EDCs and fetal growth parameters, including the head circumference (HC)/abdominal circumference (AC) ratio as an asymmetric parameter. The levels of EDCs were compared between fetuses with and without asymmetric FGR. Of the EDCs, only the fetal levels of BPA showed a linear association with the HC/AC ratio after adjusting for confounding variables (β = 0.003, p < 0.05). When comparing the normal growth and asymmetric FGR groups, the asymmetric FGR group showed significantly higher maternal and fetal BPA levels compared to the normal growth group (maternal urine BPA, 3.99 μg/g creatinine vs. 1.71 μg/g creatinine [p < 0.05]; cord blood BPA, 1.96 μg/L vs. -0.86 μg/L [p < 0.05]). In conclusion, fetal exposure levels of BPA show linear associations with asymmetric fetal growth patterns. High maternal and fetal exposure to BPA might be associated with asymmetric FGR.
摘要：
最近的证据表明，由于胎盘生长改变，内分泌干扰化学物质（EDC）与胎盘功能不全之间存在关联。合胞体,和滋养细胞入侵。然而,尚无流行病学研究报道EDC暴露与胎盘功能不全导致的不对称胎儿生长受限(FGR)之间存在关联.这项研究的目的是评估EDC暴露与不对称FGR之间的关联。这是一项前瞻性队列研究，包括2021年10月至2022年10月期间入院到首尔圣玛丽医院孕产妇胎儿中心分娩的妇女。收集产妇尿液和脐带血样本，和双酚A(BPA)的水平，邻苯二甲酸单乙酯,分析每个样本中的全氟辛酸。我们调查了EDC水平与胎儿生长参数之间的线性和非线性关联，包括头围（HC）/腹围（AC）比率作为不对称参数。比较有和没有不对称FGR的胎儿之间的EDC水平。在EDC中，在校正混杂变量后,只有胎儿BPA水平与HC/AC比值呈线性关系(β=0.003,p<0.05).当比较正常生长和不对称FGR组时，与正常生长组相比，不对称FGR组的母体和胎儿BPA水平显着升高（母体尿液BPA，3.99μg/g肌酐vs.1.71μg/g肌酐[p<0.05]；脐带血BPA，1.96μg/Lvs.-0.86μg/L[p<0.05])。总之,胎儿BPA暴露水平与不对称胎儿生长模式呈线性关系.母体和胎儿对BPA的高暴露可能与不对称FGR有关。
