METHODS: Prospective study of 431 pregnant women, their placenta, and newborns registered in the data bank of the research Group \"Salud y Comunidad César Uribe Piedrahíta\" which collected information between 2014 and 2020 in endemic municipalities of the departments of Córdoba and Antioquia. The frequency of infection was determined with 95% confidence intervals. Comparisons were made with the Chi-square test, Student t-test, prevalence ratios, and control for confounding variables by log-binomial regression.
RESULTS: The frequency of MiP was 22.3% (4.6% using TBS), PM 24.8% (1.4% using TBS), and CM 11.8% (0% using TBS). Using TBS predominated P. vivax. Using qPCR the proportions of P. vivax and P. falciparum were similar for MiP and PM, but P. falciparum predominated in CM. The frequency was higher in nulliparous, and women with previous malaria. The main clinical effects of PAM were anaemia, low birth weight, and abnormal APGAR score.
CONCLUSIONS: The magnitude of infections was not detected with TBS because most cases were submicroscopic (TBS-negative, qPCR-positive). This confirmed the importance of improving the molecular detection of cases. PAM continue being underestimated in the country due to that in Colombia the control programme is based on TBS, despite its outcomes on maternal, and congenital health.
方法:对431名孕妇进行前瞻性研究,他们的胎盘,以及在“SaludyComunidadCésarUribePiedrahíta”研究小组的数据库中注册的新生儿,该小组在2014年至2020年之间在科尔多瓦和安蒂奥基亚省的地方城市收集了信息。以95%置信区间确定感染频率。用卡方检验进行了比较,学生t检验,患病率比率,并通过对数二项回归控制混杂变量。
结果:MiP的频率为22.3%(使用TBS为4.6%),PM24.8%(使用TBS为1.4%),和厘米11.8%(0%使用TBS)。使用TBS占优势的间日疟原虫。使用qPCR,MIP和PM的间日疟原虫和恶性疟原虫的比例相似,但恶性疟原虫在CM中占主导地位。未产的频率更高,和以前患有疟疾的妇女。PAM的主要临床疗效是贫血,低出生体重,APGAR评分异常。
结论:TBS未检测到感染程度,因为大多数病例是亚显微镜下(TBS阴性,qPCR阳性)。这证实了改进病例分子检测的重要性。由于哥伦比亚的控制计划是基于TBS的,因此该国的PAM继续被低估,尽管它对产妇有影响,和先天健康。