RESULTS: The present cross-sectional research was done between 2016 and 2022 on samples in Shahid Beheshti University of Medical Sciences-affiliated hospitals in Iran. Histological tissue samples of CCs (16 AC and 48 SCC) were assessed, and clinical information was obtained by reviewing their medical documents. PD-L1 expression was evaluated by immunohistochemistry and we used the combined positive score. SCC cases showed a higher (not significant) PD-L1 expression. The PD-L1 expression and clinical characteristics were not significantly correlated in both subgroups.
CONCLUSIONS: Although SCC cases exhibited higher PD-L1 expression, this difference was non-significant. More investigations should highlight the role of PD-L1 in CC and the potential benefits of immunotherapy.
结果:本横断面研究是在2016年至2022年之间对伊朗ShahidBeheshti医科大学附属医院的样本进行的。评估CCs(16个AC和48个SCC)的组织学组织样本,临床信息是通过审查他们的医疗文件获得的。通过免疫组织化学评估PD-L1表达,我们使用联合阳性评分。SCC病例显示较高(不显著)的PD-L1表达。PD-L1表达与临床特征无显著相关性。
结论:尽管SCC病例表现出更高的PD-L1表达,这一差异并不显著.更多的研究应该强调PD-L1在CC中的作用以及免疫治疗的潜在益处。