PDF(Pubmed)
Abstract：
OBJECTIVE: Cervical cancer (CC) is a common malignancy in women, predominantly caused by human papillomavirus. The most subtypes are adenocarcinomas (AC) and squamous cell carcinomas (SCC), which show various features and treatment responses. Programmed death-ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) as Immune checkpoint molecules, play a role in immune evasion. We investigated PD-L1 expression in AC and SCC of the cervix and explored its link to clinical characteristics.
RESULTS: The present cross-sectional research was done between 2016 and 2022 on samples in Shahid Beheshti University of Medical Sciences-affiliated hospitals in Iran. Histological tissue samples of CCs (16 AC and 48 SCC) were assessed, and clinical information was obtained by reviewing their medical documents. PD-L1 expression was evaluated by immunohistochemistry and we used the combined positive score. SCC cases showed a higher (not significant) PD-L1 expression. The PD-L1 expression and clinical characteristics were not significantly correlated in both subgroups.
CONCLUSIONS: Although SCC cases exhibited higher PD-L1 expression, this difference was non-significant. More investigations should highlight the role of PD-L1 in CC and the potential benefits of immunotherapy.
RESULTS: The present cross-sectional research was done between 2016 and 2022 on samples in Shahid Beheshti University of Medical Sciences-affiliated hospitals in Iran. Histological tissue samples of CCs (16 AC and 48 SCC) were assessed, and clinical information was obtained by reviewing their medical documents. PD-L1 expression was evaluated by immunohistochemistry and we used the combined positive score. SCC cases showed a higher (not significant) PD-L1 expression. The PD-L1 expression and clinical characteristics were not significantly correlated in both subgroups.
CONCLUSIONS: Although SCC cases exhibited higher PD-L1 expression, this difference was non-significant. More investigations should highlight the role of PD-L1 in CC and the potential benefits of immunotherapy.
摘要：
目的：宫颈癌（CC）是女性常见的恶性肿瘤，主要由人乳头瘤病毒引起。大多数亚型是腺癌（AC）和鳞状细胞癌（SCC），显示各种特征和治疗反应。程序性死亡配体1（PD-L1）和程序性细胞死亡蛋白1（PD-1）作为免疫检查点分子，在免疫逃避中发挥作用。我们研究了宫颈AC和SCC中PD-L1的表达，并探讨了其与临床特征的联系。
结果：本横断面研究是在2016年至2022年之间对伊朗ShahidBeheshti医科大学附属医院的样本进行的。评估CCs（16个AC和48个SCC）的组织学组织样本，临床信息是通过审查他们的医疗文件获得的。通过免疫组织化学评估PD-L1表达，我们使用联合阳性评分。SCC病例显示较高(不显著)的PD-L1表达。PD-L1表达与临床特征无显著相关性。
结论：尽管SCC病例表现出更高的PD-L1表达，这一差异并不显著.更多的研究应该强调PD-L1在CC中的作用以及免疫治疗的潜在益处。
结果：本横断面研究是在2016年至2022年之间对伊朗ShahidBeheshti医科大学附属医院的样本进行的。评估CCs（16个AC和48个SCC）的组织学组织样本，临床信息是通过审查他们的医疗文件获得的。通过免疫组织化学评估PD-L1表达，我们使用联合阳性评分。SCC病例显示较高(不显著)的PD-L1表达。PD-L1表达与临床特征无显著相关性。
结论：尽管SCC病例表现出更高的PD-L1表达，这一差异并不显著.更多的研究应该强调PD-L1在CC中的作用以及免疫治疗的潜在益处。
