{Reference Type}: Journal Article
{Title}: Comparison of programmed death-ligand 1 expression in adenocarcinoma and squamous cell carcinoma of the cervix in paraffin blocks of patients with cervical cancer.
{Author}: Hosseini MS;Shafizadeh F;Bahremani MH;Farzaneh F;Ashrafganjoei T;Arab M;Talayeh M;Jafari F;Abdshah A;
{Journal}: Cancer Rep (Hoboken)
{Volume}: 7
{Issue}: 4
{Year}: 2024 Apr
暂无{DOI}: 10.1002/cnr2.2057
{Abstract}: <B>OBJECTIVE: </B>Cervical cancer (CC) is a common malignancy in women, predominantly caused by human papillomavirus. The most subtypes are adenocarcinomas (AC) and squamous cell carcinomas (SCC), which show various features and treatment responses. Programmed death-ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) as Immune checkpoint molecules, play a role in immune evasion. We investigated PD-L1 expression in AC and SCC of the cervix and explored its link to clinical characteristics.<BR><B>RESULTS: </B>The present cross-sectional research was done between 2016 and 2022 on samples in Shahid Beheshti University of Medical Sciences-affiliated hospitals in Iran. Histological tissue samples of CCs (16 AC and 48 SCC) were assessed, and clinical information was obtained by reviewing their medical documents. PD-L1 expression was evaluated by immunohistochemistry and we used the combined positive score. SCC cases showed a higher (not significant) PD-L1 expression. The PD-L1 expression and clinical characteristics were not significantly correlated in both subgroups.<BR><B>CONCLUSIONS: </B>Although SCC cases exhibited higher PD-L1 expression, this difference was non-significant. More investigations should highlight the role of PD-L1 in CC and the potential benefits of immunotherapy.