METHODS: In our study 30 albino Wistar rats each were used in MES and PTZ model respectively. 30 rats were divided equally into following groups: I - distilled water (negative control) II - distilled water (positive control) III - sodium valproate (300 mg/kg) IV - biotin (10 mg/kg/day) V - biotin (10 mg/kg) + sodium valproate (150 mg/kg).
RESULTS: We observed that the tonic hind limb extension was significantly reduced in the treatment group in MES model. Nitric oxide levels were also seen raised in combination group in MES model and all the treated groups in PTZ model. Biotin treated group showed increased high-density lipoproteins and reduced low density lipoproteins and triglycerides.
CONCLUSIONS: Biotin had an additive effect to sodium valproate in both the models of epilepsy in rats. Further, it was also able to counteract hyperlipidemia cause by sodium valproate.
方法:在我们的研究中,30只白化病Wistar大鼠分别用于MES和PTZ模型。将30只大鼠平均分为以下组:I-蒸馏水(阴性对照)II-蒸馏水(阳性对照)III-丙戊酸钠(300mg/kg)IV-生物素(10mg/kg/天)V-生物素(10mg/kg)+丙戊酸钠(150mg/kg)。
结果:我们观察到,在MES模型中,治疗组的后肢伸展明显减少。在MES模型中的组合组和在PTZ模型中的所有处理组中也观察到一氧化氮水平升高。生物素处理组显示增加的高密度脂蛋白和减少的低密度脂蛋白和甘油三酯。
结论:在两种大鼠癫痫模型中,生物素对丙戊酸钠都有累加作用。Further,它还能够对抗丙戊酸钠引起的高脂血症。