背景:炎症和肥胖是高脂血症的危险因素。尽管如此,缺乏关于膳食活微生物摄入与高脂血症之间关联的研究。因此,本研究的重点是揭示它们与炎症和肥胖的中介作用之间的关系。
方法:共有16,677名受试者从国家健康和营养检查调查(NHANES)(1999-2010和2015-2020)中纳入。探讨活微生物与高脂血症及血脂水平的相关性,分别,采用多元logistic回归和线性回归。此外,体重指数(BMI)的中介作用,通过中介分析探讨了C反应蛋白(Crp)及其链效应。
结果:高活微生物摄入量是高脂血症的保护因素。此外,在男性(β=2.52,95%CI:1.29,3.76,P<0.0001)和女性(β=2.22,95%CI:1.05,3.38,P<0.001)中,高摄取量与高密度脂蛋白胆固醇(HDL-C)呈正相关,但与男性甘油三酯(TG)水平(β=-7.37,95%CI:-13.16,-1.59,P=0.02)和女性低密度脂蛋白胆固醇(LDL-C)水平(β=-2.75,95%CI:-5.28,-0.21,P=0.02)呈负相关。Crp,BMI及其连锁效应介导了活微生物与HDL-C水平之间的关系。此外,BMI和链效应介导了活微生物与LDL-C水平之间的关系。
结论:饮食中的活微生物摄入与较低的高脂血症风险相关。Crp,BMI及其连锁效应对两者的关系具有中介作用。
BACKGROUND: Inflammation and obesity are the risk factors for
hyperlipidaemia. Nonetheless, research regarding the association between dietary live microbes intake and
hyperlipidaemia is lacking. Therefore, this study focused on revealing the relationship between them and mediating roles of inflammation and obesity.
METHODS: Totally 16,677 subjects were enrolled from the National Health and Nutrition Examination Survey (NHANES) (1999-2010 and 2015-2020). To explore the correlation between live microbes and
hyperlipidaemia as well as blood lipid levels, respectively, multiple logistic regression and linear regression were employed. Furthermore, the mediating roles of body mass index (BMI), C-reactive protein (Crp) and their chain effect were explored through mediating analysis.
RESULTS: High dietary live microbes intake was the protective factor for
hyperlipidaemia. In addition, high dietary live microbes intake exhibited a positive relationship to the high-density lipoprotein cholesterol (HDL-C) among males (β = 2.52, 95% CI: 1.29, 3.76, P < 0.0001) and females (β = 2.22, 95% CI: 1.05, 3.38, P < 0.001), but exhibited a negative correlation with triglyceride (TG) levels in males (β = -7.37, 95% CI: -13.16, -1.59, P = 0.02) and low-density lipoprotein cholesterol (LDL-C) levels in females (β = -2.75, 95% CI: -5.28, -0.21, P = 0.02). Crp, BMI and their chain effect mediated the relationship between live microbes with HDL-C levels. Moreover, BMI and the chain effect mediated the relationship between live microbes with LDL-C levels.
CONCLUSIONS: Dietary live microbes intake is related to a lower
hyperlipidaemia risk. Crp, BMI and their chain effect make a mediating impact on the relationship.