Abstract：
Hypertension-related diseases occur in both hypertensive and non-hypertensive individuals. However, few studies to date have explored blood pressure (BP) control in non-hypertensive individuals. This before-after study aimed to examine the impact of visual stimulation-based digital therapeutics (VS-DTx) on BP and heart rate (HR). Eighty-three eligible non-hypertensive participants were included in this study. The McNemar test and Paired Samples Wilcoxon Signed Rank Test were employed to assess decline rates and differences in BP and HR between the control phase and the intervention (using VS-DTx) phase. Pairwise correlation analysis was used to analyze the correlation between the two phases. This study found the systolic BP (SBP) and mean arterial pressure (MAP) in the VS-DTx phase showed a downward trend (66.2% vs 49.3%; 68.7% vs 55.4%). The mean SBP decreased from 114.73 mm Hg to 111.18 mm Hg, and the mean MAP decreased from 87.96 mm Hg to 84.88 mm Hg in the VS-DTx phase. Paired Samples Wilcoxon Test showed differences in both ΔSBP (Z = -3.296; P < 0.01) and ΔMAP (Z = -2.386; P < 0.05) (Δ is defined as the difference between baseline and post-stimulus). The pairwise correlations analysis revealed that VS-DTx affected the MAP reduction (r = 0.33; P < 0.01) between the browsing digital devices phase and the VS-DTx phase. The results indicated that VS-DTx may have a certain effect on BP, including SBP and MAP. This study preliminarily explored the possible effects of VS-DTx on BP, providing certain useful insights for future research in digital BP management.
摘要：
高血压相关疾病发生在高血压和非高血压个体中。然而,迄今为止，很少有研究探索非高血压个体的血压（BP）控制。这项前后研究旨在研究基于视觉刺激的数字疗法（VS-DTx）对BP和心率（HR）的影响。83名符合条件的非高血压参与者被纳入本研究。采用McNemar检验和配对样品Wilcoxon签名秩检验来评估对照阶段和干预阶段(使用VS-DTx)之间的BP和HR的下降率和差异。采用成对相关分析法分析两阶段的相关性。本研究发现VS-DTx期收缩压（SBP）和平均动脉压（MAP）呈下降趋势（66.2％vs49.3％；68.7％vs55.4％）。平均SBP从114.73mmHg降至111.18mmHg，在VS-DTx阶段，平均MAP从87.96mmHg降至84.88mmHg。配对样品Wilcoxon检验显示ΔSBP(Z=-3.296;P<0.01)和ΔMAP(Z=-2.386;P<0.05)两者的差异(Δ定义为基线和刺激后之间的差异)。两相关分析表明，VS-DTx影响浏览数字设备阶段和VS-DTx阶段之间的MAP降低（r=0.33；P<0.01）。结果表明VS-DTx对BP有一定的影响,包括SBP和MAP。本研究初步探讨了VS-DTx对BP的可能影响,为数字BP管理的未来研究提供了一些有用的见解。
