Abstract：
UNASSIGNED: To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials.
UNASSIGNED: In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT.
UNASSIGNED: We have identified seven controversies and five consensus points. Of 12 centers, 6 offer both, RHT with chemotherapy (CTX) or with radiotherapy (RT). Two centers only offer RHT with CTX and four centers only offer RHT with RT. All 12 centers apply RHT for localized, high-risk STS of the extremities, trunk wall and retroperitoneum. However, eight centers also use RHT in metastatic STS, five in palliative STS, eight for superficial STS and six for low-grade STS. Pretherapeutic imaging for RHT treatment planning is used by 10 centers, 9 centers set 40-43 °C as the intratumoral target temperature, and all centers use skin detectors or probes in body orifices for thermometry.
UNASSIGNED: There is disagreement regarding the integration of RHT in contemporary interdisciplinary care of STS patients. Many clinical controversies exist that require a standardized consensus guideline and innovative study ideas. At the same time, our data has shown that existing guidelines and decades of experience with the technique of RHT have mostly standardized procedural aspects.
UNASSIGNED: The provided results may serve as a basis for future guidelines and inform future clinical trials for RHT in STS patients.
UNASSIGNED: In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT.
UNASSIGNED: We have identified seven controversies and five consensus points. Of 12 centers, 6 offer both, RHT with chemotherapy (CTX) or with radiotherapy (RT). Two centers only offer RHT with CTX and four centers only offer RHT with RT. All 12 centers apply RHT for localized, high-risk STS of the extremities, trunk wall and retroperitoneum. However, eight centers also use RHT in metastatic STS, five in palliative STS, eight for superficial STS and six for low-grade STS. Pretherapeutic imaging for RHT treatment planning is used by 10 centers, 9 centers set 40-43 °C as the intratumoral target temperature, and all centers use skin detectors or probes in body orifices for thermometry.
UNASSIGNED: There is disagreement regarding the integration of RHT in contemporary interdisciplinary care of STS patients. Many clinical controversies exist that require a standardized consensus guideline and innovative study ideas. At the same time, our data has shown that existing guidelines and decades of experience with the technique of RHT have mostly standardized procedural aspects.
UNASSIGNED: The provided results may serve as a basis for future guidelines and inform future clinical trials for RHT in STS patients.
摘要：
■为了分析12个欧洲中心对软组织肉瘤（STS）进行区域热疗（RHT）的当前实践，以提供概述，寻找共识，并确定未来指南和临床试验所需的争议。
■在这项横断面调查研究中，我们向12个欧洲RHT中心分发了一份27项问卷,评估STSRHT的临床受试者和手术细节.
■我们已经确定了七个争议和五个共识点。在12个中心中，6提供两者，RHT联合化疗（CTX）或放疗（RT）。两个中心仅提供带有CTX的RHT，四个中心仅提供带有RT的RHT。所有12个中心都将RHT应用于本地化，四肢高危STS,躯干壁和腹膜后。然而,八个中心也在转移性STS中使用RHT，五个在姑息性STS中，八用于表面STS，六用于低级STS。10个中心使用RHT治疗计划的治疗前成像，9个中心设置40-43°C作为肿瘤内目标温度，和所有中心使用皮肤探测器或探头在身体孔进行测温。
■关于RHT在当代STS患者跨学科护理中的整合存在分歧。存在许多临床争议，需要标准化的共识指南和创新的研究思路。同时,我们的数据表明,现有的指南和数十年的RHT技术经验大多具有标准化的程序方面.
■提供的结果可以作为未来指南的基础，并为STS患者的RHT的未来临床试验提供信息。
■在这项横断面调查研究中，我们向12个欧洲RHT中心分发了一份27项问卷,评估STSRHT的临床受试者和手术细节.
■我们已经确定了七个争议和五个共识点。在12个中心中，6提供两者，RHT联合化疗（CTX）或放疗（RT）。两个中心仅提供带有CTX的RHT，四个中心仅提供带有RT的RHT。所有12个中心都将RHT应用于本地化，四肢高危STS,躯干壁和腹膜后。然而,八个中心也在转移性STS中使用RHT，五个在姑息性STS中，八用于表面STS，六用于低级STS。10个中心使用RHT治疗计划的治疗前成像，9个中心设置40-43°C作为肿瘤内目标温度，和所有中心使用皮肤探测器或探头在身体孔进行测温。
■关于RHT在当代STS患者跨学科护理中的整合存在分歧。存在许多临床争议，需要标准化的共识指南和创新的研究思路。同时,我们的数据表明,现有的指南和数十年的RHT技术经验大多具有标准化的程序方面.
■提供的结果可以作为未来指南的基础，并为STS患者的RHT的未来临床试验提供信息。
