PDF(Pubmed)
Abstract：
UNASSIGNED: Migraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used in this study to explore whether immune diseases are causally associated with migraine and its subtypes.
UNASSIGNED: We conducted a two-sample bidirectional multivariate Mendelian randomization study. Single-nucleotide polymorphisms (SNP) for six immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), allergic rhinitis (AR), asthma and psoriasis, were used as genetic instrumental variables. Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and FinnGen study. MR analyses were performed per outcome database for each exposure and subsequently meta-analyzed. Reverse MR analysis was performed to determine whether migraine were risk factors for immune diseases. In addition, we conducted a genetic correlation to identify shared genetic variants for these two associations.
UNASSIGNED: No significant causal relationship was found between immune diseases and migraine and its subtypes. These results were robust with a series of sensitivity analyses. Using the linkage disequilibrium score regression method (LDSC), we detected no genetic correlation between migraine and immune diseases.
UNASSIGNED: The evidence from our study does not support a causal relationship between immune diseases and migraine. The mechanisms underlying the frequent comorbidity of migraine and several immune diseases need to be further elucidated.
UNASSIGNED: We conducted a two-sample bidirectional multivariate Mendelian randomization study. Single-nucleotide polymorphisms (SNP) for six immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), allergic rhinitis (AR), asthma and psoriasis, were used as genetic instrumental variables. Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and FinnGen study. MR analyses were performed per outcome database for each exposure and subsequently meta-analyzed. Reverse MR analysis was performed to determine whether migraine were risk factors for immune diseases. In addition, we conducted a genetic correlation to identify shared genetic variants for these two associations.
UNASSIGNED: No significant causal relationship was found between immune diseases and migraine and its subtypes. These results were robust with a series of sensitivity analyses. Using the linkage disequilibrium score regression method (LDSC), we detected no genetic correlation between migraine and immune diseases.
UNASSIGNED: The evidence from our study does not support a causal relationship between immune diseases and migraine. The mechanisms underlying the frequent comorbidity of migraine and several immune diseases need to be further elucidated.
摘要：
■偏头痛在几种免疫疾病中的患病率增加，但遗传因果关系仍不清楚。在这项研究中使用孟德尔随机化（MR）来探索免疫性疾病是否与偏头痛及其亚型有因果关系。
■我们进行了双样本双向多变量孟德尔随机化研究。六种免疫性疾病的单核苷酸多态性（SNP），包括类风湿性关节炎（RA），系统性红斑狼疮（SLE），1型糖尿病（T1D），过敏性鼻炎（AR），哮喘和牛皮癣，被用作遗传工具变量。偏头痛的汇总统计数据来自3个数据库：国际头痛遗传学协会（IHGC），英国生物银行,和FinnGen研究。对每个暴露的结果数据库进行MR分析，随后进行荟萃分析。进行反向MR分析以确定偏头痛是否是免疫性疾病的危险因素。此外,我们进行了遗传相关,以确定这两种关联的共有遗传变异.
■在免疫性疾病和偏头痛及其亚型之间没有发现显著的因果关系。通过一系列敏感性分析，这些结果是稳健的。使用连锁不平衡分数回归方法(LDSC)，我们检测到偏头痛与免疫性疾病之间没有遗传相关性。
■我们研究的证据不支持免疫疾病和偏头痛之间的因果关系。偏头痛和几种免疫疾病频繁共病的潜在机制需要进一步阐明。
■我们进行了双样本双向多变量孟德尔随机化研究。六种免疫性疾病的单核苷酸多态性（SNP），包括类风湿性关节炎（RA），系统性红斑狼疮（SLE），1型糖尿病（T1D），过敏性鼻炎（AR），哮喘和牛皮癣，被用作遗传工具变量。偏头痛的汇总统计数据来自3个数据库：国际头痛遗传学协会（IHGC），英国生物银行,和FinnGen研究。对每个暴露的结果数据库进行MR分析，随后进行荟萃分析。进行反向MR分析以确定偏头痛是否是免疫性疾病的危险因素。此外,我们进行了遗传相关,以确定这两种关联的共有遗传变异.
■在免疫性疾病和偏头痛及其亚型之间没有发现显著的因果关系。通过一系列敏感性分析，这些结果是稳健的。使用连锁不平衡分数回归方法(LDSC)，我们检测到偏头痛与免疫性疾病之间没有遗传相关性。
■我们研究的证据不支持免疫疾病和偏头痛之间的因果关系。偏头痛和几种免疫疾病频繁共病的潜在机制需要进一步阐明。
