%0 Journal Article
%T Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study.
%A Li G
%A Duan S
%A  
%A Zheng T
%A Zhu T
%A Qu B
%A Liu L
%A Liu Z
%J Front Immunol
%V 15
%N 0
%D 2024
%M 38650934
%F 8.786
%R 10.3389/fimmu.2024.1376698
%X <B>UNASSIGNED: </B>Migraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used in this study to explore whether immune diseases are causally associated with migraine and its subtypes.<BR><B>UNASSIGNED: </B>We conducted a two-sample bidirectional multivariate Mendelian randomization study. Single-nucleotide polymorphisms (SNP) for six immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), allergic rhinitis (AR), asthma and psoriasis, were used as genetic instrumental variables. Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and FinnGen study. MR analyses were performed per outcome database for each exposure and subsequently meta-analyzed. Reverse MR analysis was performed to determine whether migraine were risk factors for immune diseases. In addition, we conducted a genetic correlation to identify shared genetic variants for these two associations.<BR><B>UNASSIGNED: </B>No significant causal relationship was found between immune diseases and migraine and its subtypes. These results were robust with a series of sensitivity analyses. Using the linkage disequilibrium score regression method (LDSC), we detected no genetic correlation between migraine and immune diseases.<BR><B>UNASSIGNED: </B>The evidence from our study does not support a causal relationship between immune diseases and migraine. The mechanisms underlying the frequent comorbidity of migraine and several immune diseases need to be further elucidated.