Abstract：
UNASSIGNED: Dysfunctional sensory gating in anxiety disorders, indexed by the failure to inhibit the P50 event-related potential (ERP) to repeated stimuli, has been linked to deficits in the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
UNASSIGNED: This study, conducted in 30 healthy volunteers, examined the acute effects of GABAA (lorazepam: 1 mg) and GABAB receptor (baclofen: 10 mg) agonists on P50 measures of auditory sensory gating within a paired-stimulus (S1-S2) paradigm and assessed changes in gating in relation to self-ratings of anxiety.
UNASSIGNED: Compared to placebo, lorazepam reduced ERP indices of sensory gating by attenuating response to S1. Although not directly impacting P50 inhibition, baclofen-induced changes in gating (relative to placebo) were negatively correlated with trait but not state anxiety.
UNASSIGNED: These preliminary findings support the involvement of GABA in sensory gating and tentatively suggest a role for GABAB receptor signaling in anxiety-associated gating dysregulation.
UNASSIGNED: This study, conducted in 30 healthy volunteers, examined the acute effects of GABAA (lorazepam: 1 mg) and GABAB receptor (baclofen: 10 mg) agonists on P50 measures of auditory sensory gating within a paired-stimulus (S1-S2) paradigm and assessed changes in gating in relation to self-ratings of anxiety.
UNASSIGNED: Compared to placebo, lorazepam reduced ERP indices of sensory gating by attenuating response to S1. Although not directly impacting P50 inhibition, baclofen-induced changes in gating (relative to placebo) were negatively correlated with trait but not state anxiety.
UNASSIGNED: These preliminary findings support the involvement of GABA in sensory gating and tentatively suggest a role for GABAB receptor signaling in anxiety-associated gating dysregulation.
摘要：
■焦虑症的感觉门控功能失调，以未能抑制P50事件相关电位(ERP)对重复刺激为索引，与主要抑制性神经递质γ-氨基丁酸（GABA）的缺陷有关。
■这项研究，在30名健康志愿者中进行，检查了GABAA(劳拉西泮:1mg)和GABAB受体(巴氯芬:10mg)激动剂在配对刺激(S1-S2)模式下对听觉感觉门控P50测量值的急性影响,并评估了门控与焦虑自我评分相关的变化。
■与安慰剂相比，劳拉西m通过减弱对S1的反应来降低感觉门控的ERP指数。虽然不直接影响P50抑制，巴氯芬诱导的门控变化（相对于安慰剂）与性状呈负相关，而与状态焦虑无关。
■这些初步发现支持GABA参与感觉门控，并初步提示GABAB受体信号在焦虑相关门控失调中的作用。
■这项研究，在30名健康志愿者中进行，检查了GABAA(劳拉西泮:1mg)和GABAB受体(巴氯芬:10mg)激动剂在配对刺激(S1-S2)模式下对听觉感觉门控P50测量值的急性影响,并评估了门控与焦虑自我评分相关的变化。
■与安慰剂相比，劳拉西m通过减弱对S1的反应来降低感觉门控的ERP指数。虽然不直接影响P50抑制，巴氯芬诱导的门控变化（相对于安慰剂）与性状呈负相关，而与状态焦虑无关。
■这些初步发现支持GABA参与感觉门控，并初步提示GABAB受体信号在焦虑相关门控失调中的作用。
