%0 Journal Article
%T Influence of GABAA and GABAB receptor activation on auditory sensory gating and its association with anxiety in healthy volunteers.
%A de la Salle S
%A Piche J
%A Duncan B
%A Choueiry J
%A Hyde M
%A Aidelbaum R
%A Baddeley A
%A Impey D
%A Rahmani N
%A Ilivitsky V
%A Knott V
%J J Psychopharmacol
%V 38
%N 6
%D 2024 Jun 22
%M 38647196
%F 4.562
%R 10.1177/02698811241246854
%X <B>UNASSIGNED: </B>Dysfunctional sensory gating in anxiety disorders, indexed by the failure to inhibit the P50 event-related potential (ERP) to repeated stimuli, has been linked to deficits in the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).<BR><B>UNASSIGNED: </B>This study, conducted in 30 healthy volunteers, examined the acute effects of GABAA (lorazepam: 1 mg) and GABAB receptor (baclofen: 10 mg) agonists on P50 measures of auditory sensory gating within a paired-stimulus (S1-S2) paradigm and assessed changes in gating in relation to self-ratings of anxiety.<BR><B>UNASSIGNED: </B>Compared to placebo, lorazepam reduced ERP indices of sensory gating by attenuating response to S1. Although not directly impacting P50 inhibition, baclofen-induced changes in gating (relative to placebo) were negatively correlated with trait but not state anxiety.<BR><B>UNASSIGNED: </B>These preliminary findings support the involvement of GABA in sensory gating and tentatively suggest a role for GABAB receptor signaling in anxiety-associated gating dysregulation.