Abstract：
I was fortunate enough to start my career at what was the dawn of modern-day molecular biology and to apply it to an important health problem. While my early work focused on fundamental science, the desire to understand human disease better and to find practical applications for research discoveries resulted, over the following decades, in creating a stream of translational research directed specifically toward epithelial cancers. This could only have been possible through multiple collaborations. This type of team science would eventually become a hallmark of my career. With the development of higher throughput molecular techniques, the pace of research and discovery has quickened, and the concept of personalized medicine based on genomics is now coming to fruition. I hope my legacy will not just reflect my published works, but will also include the impact I have had on the development of the next generation of scientists and clinician scientists who inspired me with their dedication, knowledge, and enthusiasm.
摘要：
我很幸运地从现代分子生物学的曙光开始我的职业生涯，并将其应用于一个重要的健康问题。虽然我早期的工作重点是基础科学，更好地了解人类疾病并为研究发现找到实际应用的愿望，在接下来的几十年里，创造了一系列专门针对上皮癌的转化研究。只有通过多种合作才能做到这一点。这种团队科学最终将成为我职业生涯的标志。随着高通量分子技术的发展,研究和发现的步伐加快了，基于基因组学的个性化医疗概念现在正在实现。我希望我的遗产不会只反映我发表的作品，还将包括我对下一代科学家和临床科学家的发展产生的影响，他们的奉献精神激励了我，知识和热情。
