Abstract：
OBJECTIVE: This study aimed to evaluate the efficacy and safety of applying 5% lidocaine cream to the sensitive area of the glans penis after its precise localization under the penile biological vibration threshold test for the treatment of primary premature ejaculation.
METHODS: Eighty patients diagnosed with primary premature ejaculation in an outpatient setting were included in this study. They were randomly scored into two groups. Group 1 (n = 40) was given 1 ml of 5% lidocaine cream on demand. They were instructed to apply the lidocaine cream evenly in a circular pattern to the glans penis without precise application to the sensitive area of the glans penis. The treatment lasted for a total of 4 weeks. Group 2 (n = 40) had a penile biological vibration threshold test performed to detect loci with a lower threshold. They were instructed to apply 1 ml of 5% lidocaine cream to the sensitive loci on the glans penis for 4 weeks. Lidocaine cream was applied topically or uniformly to the glans penis 20 minutes before planned intercourse in both groups .The efficacy and side effects before and after treatment were evaluated by the intravaginal ejaculation latency (IELTs) before and after treatment, combined with the Arabic Index of Premature Ejaculation and IIEF-5 score.
RESULTS: After treatment, IELTs in both groups were significantly improved compared with those before treatment(P<0.05);The Arab premature ejaculation index and IIEF-5 score of the precise smear group are higher than those of the uniform smear group(P<0.05).
CONCLUSIONS: This study infers that applying lidocaine according to the threshold of penile and glans vibration has a positive effect and fewer adverse event reports compared with the traditional method of using surface anesthetics, which is worthy of clinical promotion.
METHODS: Eighty patients diagnosed with primary premature ejaculation in an outpatient setting were included in this study. They were randomly scored into two groups. Group 1 (n = 40) was given 1 ml of 5% lidocaine cream on demand. They were instructed to apply the lidocaine cream evenly in a circular pattern to the glans penis without precise application to the sensitive area of the glans penis. The treatment lasted for a total of 4 weeks. Group 2 (n = 40) had a penile biological vibration threshold test performed to detect loci with a lower threshold. They were instructed to apply 1 ml of 5% lidocaine cream to the sensitive loci on the glans penis for 4 weeks. Lidocaine cream was applied topically or uniformly to the glans penis 20 minutes before planned intercourse in both groups .The efficacy and side effects before and after treatment were evaluated by the intravaginal ejaculation latency (IELTs) before and after treatment, combined with the Arabic Index of Premature Ejaculation and IIEF-5 score.
RESULTS: After treatment, IELTs in both groups were significantly improved compared with those before treatment(P<0.05);The Arab premature ejaculation index and IIEF-5 score of the precise smear group are higher than those of the uniform smear group(P<0.05).
CONCLUSIONS: This study infers that applying lidocaine according to the threshold of penile and glans vibration has a positive effect and fewer adverse event reports compared with the traditional method of using surface anesthetics, which is worthy of clinical promotion.
摘要：
目的：本研究旨在评估在阴茎生物振动阈值测试下精确定位后，将5％利多卡因乳膏应用于龟头敏感区域治疗原发性早泄的有效性和安全性。
方法：本研究纳入80例门诊诊断为原发性早泄的患者。随机分为两组。第1组(n=40)按需给予1ml5%利多卡因乳膏。他们被指示将利多卡因乳膏以圆形图案均匀地应用于龟头阴茎,而不精确地应用于龟头阴茎的敏感区域。治疗共4周。第2组（n=40）进行了阴茎生物振动阈值测试，以检测阈值较低的基因座。指示他们将1ml的5％利多卡因乳膏应用于龟头上的敏感部位4周。在计划的性交前20分钟，将利多卡因乳膏局部或均匀地应用于龟头。通过治疗前后阴道内射精潜伏期(IELTs)评价治疗前后的疗效和副作用,结合阿拉伯语早泄指数和IIEF-5评分。
结果：治疗后，两组IELTs均较治疗前明显改善(P<0.05);精确涂片组阿拉伯早泄指数和IIEF-5评分均高于均匀涂片组(P<0.05)。
结论：这项研究推断，与使用表面麻醉药的传统方法相比，根据阴茎和龟头振动的阈值应用利多卡因具有积极作用，不良事件报告更少，值得临床推广。
方法：本研究纳入80例门诊诊断为原发性早泄的患者。随机分为两组。第1组(n=40)按需给予1ml5%利多卡因乳膏。他们被指示将利多卡因乳膏以圆形图案均匀地应用于龟头阴茎,而不精确地应用于龟头阴茎的敏感区域。治疗共4周。第2组（n=40）进行了阴茎生物振动阈值测试，以检测阈值较低的基因座。指示他们将1ml的5％利多卡因乳膏应用于龟头上的敏感部位4周。在计划的性交前20分钟，将利多卡因乳膏局部或均匀地应用于龟头。通过治疗前后阴道内射精潜伏期(IELTs)评价治疗前后的疗效和副作用,结合阿拉伯语早泄指数和IIEF-5评分。
结果：治疗后，两组IELTs均较治疗前明显改善(P<0.05);精确涂片组阿拉伯早泄指数和IIEF-5评分均高于均匀涂片组(P<0.05)。
结论：这项研究推断，与使用表面麻醉药的传统方法相比，根据阴茎和龟头振动的阈值应用利多卡因具有积极作用，不良事件报告更少，值得临床推广。
