METHODS: Single-center retrospective cohort study.
METHODS: Grade-A tertiary hospital.
METHODS: A retrospective analysis of patients with early-stage (Tis-T2) glottic cancer who underwent CO2 TOLMS. All patients had at least 2 years of follow-up. The univariate and multivariate survival analyses were used to identify the risk factors for recurrence and the Kaplan-Meier method was used to analyze OS and DSS rates.
RESULTS: A total of 102 patients were included in the study. Eleven patients (10.78%) had recurrence. The univariate analysis showed that the recurrence was associated with the AC classification, T staging, tumor size, and tobacco use (P < .05). However, on multivariate analysis, the AC classification was the only independent risk factor for recurrence (P < .001, HR = 3.179). AC classification were distributed as follows: 59 (57.84%) AC0, 29 (28.43%) AC1, 8 (7.84%) AC2, and 6 (5.88%) AC3, 2-year/5-year OS and DSS rates were progressively reduced in the AC0, AC1, AC2, and AC3 groups (P < .001). At the same T staging, the OS rates incrementally decreased as the level of involvement of the AC became higher (P = .004).
CONCLUSIONS: CO2 TOLMS is an effective treatment for early-stage glottic cancer. AC involvement is an independent risk factors for recurrence and poor prognosis. The AC classification system may be better at grading the prognosis of patients with early-stage glottic cancer and has prognostic value independent of T staging.
方法:单中心回顾性队列研究。
方法:三级甲等医院。
方法:对接受CO2TOLMS的早期(Tis-T2)声门型喉癌患者进行回顾性分析。所有患者都有至少2年的随访。使用单因素和多因素生存分析来确定复发的危险因素,并使用Kaplan-Meier方法分析OS和DSS率。
结果:本研究共纳入102例患者。11例(10.78%)患者复发。单因素分析显示复发与AC分类有关,T分期,肿瘤大小,和烟草使用(P<0.05)。然而,在多变量分析中,AC分级是复发的唯一独立危险因素(P<.001,HR=3.179).AC分类分布如下:59(57.84%)AC0,29(28.43%)AC1,8(7.84%)AC2和6(5.88%)AC3,2年/5年OS和DSS率在AC0,AC1,AC2和AC3组中逐渐降低(P<0.001)。在同一个T分期,随着AC的参与程度升高,OS率逐渐降低(P=.004)。
结论:CO2TOLMS是治疗早期声门型喉癌的有效方法。AC受累是复发和预后不良的独立危险因素。AC分类系统可能更好地对早期声门型喉癌患者的预后进行分级,并且具有独立于T分期的预后价值。