{Reference Type}: Journal Article
{Title}: Oncological Outcomes of Transoral Laser Microsurgery for Early Stage Glottic Cancer with Involvement of the Anterior Commissure.
{Author}: Wang D;Liu Y;Wen L;Li S;Zhu S;Wang T;Yu D;
{Journal}: Otolaryngol Head Neck Surg
{Volume}: 171
{Issue}: 1
{Year}: 2024 Jul 19
{Factor}: 5.591
{DOI}: 10.1002/ohn.767
{Abstract}: <B>OBJECTIVE: </B>To assess the value of carbon dioxide transoral laser microsurgery (CO2 TOLMS) for early-stage glottic cancer with special regard to involvement of the anterior commissure (AC).<BR><B>METHODS: </B>Single-center retrospective cohort study.<BR><B>METHODS: </B>Grade-A tertiary hospital.<BR><B>METHODS: </B>A retrospective analysis of patients with early-stage (Tis-T2) glottic cancer who underwent CO2 TOLMS. All patients had at least 2 years of follow-up. The univariate and multivariate survival analyses were used to identify the risk factors for recurrence and the Kaplan-Meier method was used to analyze OS and DSS rates.<BR><B>RESULTS: </B>A total of 102 patients were included in the study. Eleven patients (10.78%) had recurrence. The univariate analysis showed that the recurrence was associated with the AC classification, T staging, tumor size, and tobacco use (P < .05). However, on multivariate analysis, the AC classification was the only independent risk factor for recurrence (P < .001, HR = 3.179). AC classification were distributed as follows: 59 (57.84%) AC0, 29 (28.43%) AC1, 8 (7.84%) AC2, and 6 (5.88%) AC3, 2-year/5-year OS and DSS rates were progressively reduced in the AC0, AC1, AC2, and AC3 groups (P < .001). At the same T staging, the OS rates incrementally decreased as the level of involvement of the AC became higher (P = .004).<BR><B>CONCLUSIONS: </B>CO2 TOLMS is an effective treatment for early-stage glottic cancer. AC involvement is an independent risk factors for recurrence and poor prognosis. The AC classification system may be better at grading the prognosis of patients with early-stage glottic cancer and has prognostic value independent of T staging.