METHODS: A retrospective analysis was conducted for all histopathological confirmed medulloblastomas in pediatric patients (<16 years old) that were operated on in Kuwait over the past ten years (n = 44). The radiological, histological, and molecular characteristics were justifiably evaluated and analyzed in our sample.
RESULTS: The overall progression-free survival after one year was noticed among 27 cases (≈44%) and the nonspecific 5-year survival was seen in 31 cases (≈70%) after a 5-year follow-up. Sonic Hedgehog and Wingless had the best outcomes, while group 3 showed the worst outcomes.
CONCLUSIONS: Our findings did not support the association between most of the typical magnetic resonance imaging characteristics and survival rate. We further established that Sonic Hedgehog and Wingless biological types have a better prognosis. There was no association observed between the radiographic features, specifically the location, and the molecular subtype.
目的:我们旨在深入研究髓母细胞瘤的分子亚型与影像学特征之间的关联。此外,我们的目的是研究这种相关性与无进展生存期(PFS)和5年生存率的疗效.
方法:对过去10年在科威特接受手术的所有经组织病理学证实的髓母细胞瘤患儿(<16岁)进行回顾性分析(n=44)。放射学,组织学,和分子特征在我们的样本中进行了合理的评估和分析。
结果:观察到27例患者一年后的总体无进展生存期(≈44%),31例非特异性五年生存率(≈70%)随访5年。SHH和WNT有最好的结果,而第3组的结局最差。
结论:我们的发现不支持大多数典型MRI特征与生存率之间的关联。我们进一步确定SHH和WNT生物类型具有更好的预后。射线照相特征之间没有观察到关联,特别是位置,和分子亚型。