METHODS: We assessed 26 healthy adult controls and 31 epilepsy patients (16 focal-onset, 13 generalized-onset, 2 unknown-onset) with the VPCT using delays of 2 or 30 s between encoding and recognition. Fifteen healthy controls and 17 epilepsy patients (10 focal-onset, 5 generalized-onset, 2 unknown-onset) completed the task at 2-, 5-, and 30-minute delays. Subjects also performed standard memory measures, including the Medical College of Georgia (MCG) Paragraph Test, California Verbal Learning Test-Second Edition (CVLT-II), and Brief Visual Memory Test-Revised (BVMT-R).
RESULTS: The epilepsy group was high functioning, with greater estimated IQ (p = 0.041), greater years of education (p = 0.034), and higher BVMT-R scores (p = 0.024) compared to controls. Both the control group and epilepsy cohort, as well as focal- and generalized-onset subgroups, had intact novelty preference at the 2- and 30-second delays (p-values ≤ 0.001) and declined at 30 min (p-values > 0.05). Only the epilepsy patients had early declines at 2- and 5-minute delays (controls with intact novelty preference at p = 0.003 and p ≤ 0.001, respectively; epilepsy groups\' p-values > 0.05).
CONCLUSIONS: Memory for the \"old\" items decayed more rapidly in overall, focal-onset, and generalized-onset epilepsy groups. The VPCT detected deficits while standard memory measures were largely intact, suggesting that the VPCT may be a more sensitive measure of temporal lobe memory function than standard neuropsychological batteries.
方法:我们评估了26名健康成人对照和31名癫痫患者(16例局灶性发作,13全身发作,2未知发作),VPCT在编码和识别之间使用2或30s的延迟。15名健康对照和17名癫痫患者(10名局灶性发作,5全身发作,2未知-发作)在2-完成任务,5-,和30分钟的延迟。受试者还进行了标准的记忆测量,包括佐治亚州医学院(MCG)段落测试,加州言语学习测试-第二版(CVLT-II),和简要视觉记忆测试-修订(BVMT-R)。
结果:癫痫组高功能,具有更大的估计智商(p=0.041),更大的教育年限(p=0.034),与对照组相比,BVMT-R评分更高(p=0.024)。对照组和癫痫队列,以及病灶性和广泛性亚组,在2秒和30秒延迟(p值≤0.001)时具有完整的新颖性偏好,并在30分钟时下降(p值>0.05)。只有癫痫患者在2分钟和5分钟延迟时出现早期下降(对照组具有完整的新颖性偏好,分别为p=0.003和p≤0.001;癫痫组p值>0.05)。
结论:“旧”项目的记忆总体上衰减得更快,局灶性发作,和泛发性癫痫组。VPCT检测到缺陷,而标准记忆测量基本完好无损,这表明VPCT可能比标准神经心理电池更敏感地测量颞叶记忆功能。