Abstract：
Four undescribed prenylated flavonoids, sophoratones A-D (1-4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide induced mouse in RAW 264.7 cells was assayed. The results indicated that some compounds exhibited clear inhibitory effects, with IC50 ranging from 19.91±1.08 to 35.72±2.92 μM. These results suggest that prenylated flavonoids from the aerial parts of S. tonkinensis could potentially be used as a latent source of anti-inflammatory agents.
摘要：
四种未描述的异戊烯化类黄酮，苦参A-D（1-4），和17种已知的类黄酮，是从山豆根的地上部分获得的。通过详细解释NMR光谱阐明了它们具有绝对构型的结构，质谱,和ECD计算。同时,测定了这些化合物在RAW264.7细胞中抑制脂多糖诱导的小鼠释放一氧化氮（NO）的能力。结果表明,部分化合物具有明显的抑制作用,IC50范围为19.91±1.08至35.72±2.92µM。这些结果表明，来自山葵地上部分的异戊烯化类黄酮可以潜在地用作抗炎剂的潜在来源。
