KLF13 通过直接结合 SM22 α 启动子促进 VSMCs 表型去分化。
关键词: Krüppel‐like factor 13 SM22α atherosclerosis dedifferentiation re‐stenosis vascular smooth muscle cells
Mesh : Animals Humans Male Mice Atherosclerosis / genetics pathology metabolism Carotid Artery Injuries / pathology genetics metabolism Cell Dedifferentiation Cell Movement / genetics Cell Proliferation / genetics Cells, Cultured Kruppel-Like Transcription Factors / metabolism genetics Mice, Inbred C57BL Muscle Proteins / genetics Muscle, Smooth, Vascular / metabolism pathology Myocytes, Smooth Muscle / metabolism pathology Neointima / metabolism pathology genetics Phenotype Plaque, Atherosclerotic / pathology metabolism genetics Promoter Regions, Genetic / genetics Proto-Oncogene Proteins c-akt / metabolism Repressor Proteins / genetics metabolism Signal Transduction Cell Cycle Proteins Microfilament Proteins / genetics