PDF(Pubmed)
Abstract：
Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the pathophysiological mechanism of Alzheimer\'s disease (AD).
Ten cognitively impaired (CI) individuals and 10 healthy controls (HCs) underwent [18F]SynVesT-1 and [18F]PSS232 positron emission tomography (PET)/magnetic resonance to assess synaptic density and mGluR5 availability. The associations between mGluR5 availability and synaptic density were examined. A mediation analysis was performed to investigate the possible mediating effects of mGluR5 availability and synaptic loss on the relationship between amyloid deposition and cognition.
CI patients exhibited lower mGluR5 availability and synaptic density in the medial temporal lobe than HCs. Regional synaptic density was closely associated with regional mGluR5 availability. mGluR5 availability and synaptic loss partially mediated the relationship between amyloid deposition and cognition.
Reductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD and are closely linked.
Cognitively impaired patients exhibited lower mGluR5 availability and synaptic density in the medial temporal lobe than HCs. Reductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD. Regional synaptic density was closely associated with regional mGluR5 availability. mGluR5 availability and synaptic loss partially mediated the relationship between amyloid deposition and global cognition. With further research, modulating mGluR5 availability might be a potential therapeutic strategy for improving synaptic function in AD.
Ten cognitively impaired (CI) individuals and 10 healthy controls (HCs) underwent [18F]SynVesT-1 and [18F]PSS232 positron emission tomography (PET)/magnetic resonance to assess synaptic density and mGluR5 availability. The associations between mGluR5 availability and synaptic density were examined. A mediation analysis was performed to investigate the possible mediating effects of mGluR5 availability and synaptic loss on the relationship between amyloid deposition and cognition.
CI patients exhibited lower mGluR5 availability and synaptic density in the medial temporal lobe than HCs. Regional synaptic density was closely associated with regional mGluR5 availability. mGluR5 availability and synaptic loss partially mediated the relationship between amyloid deposition and cognition.
Reductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD and are closely linked.
Cognitively impaired patients exhibited lower mGluR5 availability and synaptic density in the medial temporal lobe than HCs. Reductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD. Regional synaptic density was closely associated with regional mGluR5 availability. mGluR5 availability and synaptic loss partially mediated the relationship between amyloid deposition and global cognition. With further research, modulating mGluR5 availability might be a potential therapeutic strategy for improving synaptic function in AD.
摘要：
背景：代谢型谷氨酸受体5（mGluR5）参与调节整合脑功能和突触传递。异常的mGluR5信号传导和相关的突触衰竭在阿尔茨海默病(AD)的病理生理机制中起着关键作用。
方法：10名认知障碍（CI）个体和10名健康对照（HC）接受了[18F]SynVesT-1和[18F]PSS232正电子发射断层扫描（PET）/磁共振检查，以评估突触密度和mGluR5可用性。检查了mGluR5可用性和突触密度之间的关联。进行了介导分析，以研究mGluR5可用性和突触丢失对淀粉样蛋白沉积与认知之间关系的可能介导作用。
结果：CI患者在内侧颞叶的mGluR5可用性和突触密度低于HC。区域突触密度与区域mGluR5可用性密切相关。mGluR5可用性和突触丢失部分介导了淀粉样蛋白沉积和认知之间的关系。
结论：mGluR5可用性和突触密度的降低在AD中表现出相似的空间模式，并且密切相关。
结论：认知障碍患者在内侧颞叶的mGluR5可用性和突触密度低于HC。mGluR5可用性和突触密度的降低在AD中表现出相似的空间模式。区域突触密度与区域mGluR5可用性密切相关。mGluR5可用性和突触丢失部分介导了淀粉样蛋白沉积和整体认知之间的关系。随着进一步的研究,调节mGluR5的可用性可能是改善AD突触功能的潜在治疗策略。
方法：10名认知障碍（CI）个体和10名健康对照（HC）接受了[18F]SynVesT-1和[18F]PSS232正电子发射断层扫描（PET）/磁共振检查，以评估突触密度和mGluR5可用性。检查了mGluR5可用性和突触密度之间的关联。进行了介导分析，以研究mGluR5可用性和突触丢失对淀粉样蛋白沉积与认知之间关系的可能介导作用。
结果：CI患者在内侧颞叶的mGluR5可用性和突触密度低于HC。区域突触密度与区域mGluR5可用性密切相关。mGluR5可用性和突触丢失部分介导了淀粉样蛋白沉积和认知之间的关系。
结论：mGluR5可用性和突触密度的降低在AD中表现出相似的空间模式，并且密切相关。
结论：认知障碍患者在内侧颞叶的mGluR5可用性和突触密度低于HC。mGluR5可用性和突触密度的降低在AD中表现出相似的空间模式。区域突触密度与区域mGluR5可用性密切相关。mGluR5可用性和突触丢失部分介导了淀粉样蛋白沉积和整体认知之间的关系。随着进一步的研究,调节mGluR5的可用性可能是改善AD突触功能的潜在治疗策略。
