PDF(Pubmed)
Abstract：
OBJECTIVE: Adolescents and young adults (AYAs) experience vast symptom burden resulting from cancer treatment-related toxicities (TRTs). Evidence supports integrated exercise to mitigate several TRTs in other cohorts; however, evidence in AYAs is lacking. Conventional reporting of TRTs adopts a maximum grade approach failing to recognise the trajectory over time, of persistent, or lower grade toxicities. Alternatively, longitudinal analysis of toxicities over time (ToxT) may provide clinically meaningful summaries of this data. We evaluated the longitudinal impact of an exercise intervention on TRTs in AYAs undergoing cancer treatment.
METHODS: A prospective, randomised trial allocated participants to a 10-week exercise intervention (EG) or control group (CG) undergoing usual care. Detailed information on TRTs was collected throughout the intervention. All TRTs were graded per the Common Terminology Criteria for Adverse Events (CTCAE v5.0).
RESULTS: Forty-three (43) participants (63% male, mean age 21.1 years) were enrolled. When categorised to reflect the maximal worst grade experienced (Grade 0, Grade 1-2 and ≥ Grade 3), the CG reported an increased incidence of severe fatigue (≥ Grade 3) compared with the EG (p = 0.05). No other differences between groups were evident (p > 0.05). ToxT analysis of the four most common toxicities (fatigue, pain, nausea and mood disturbances) demonstrated no difference in the mean grade of each over time (p > 0.05).
CONCLUSIONS: A 10-week exercise intervention reduces the severity of fatigue in AYAs undergoing treatment. While the ToxT approach provided insight into the toxicity profile, adequately powered studies are needed to better understand these differences within a homogenous sample.
BACKGROUND: (ACTRN12620000663954) 10th June 2020.
METHODS: A prospective, randomised trial allocated participants to a 10-week exercise intervention (EG) or control group (CG) undergoing usual care. Detailed information on TRTs was collected throughout the intervention. All TRTs were graded per the Common Terminology Criteria for Adverse Events (CTCAE v5.0).
RESULTS: Forty-three (43) participants (63% male, mean age 21.1 years) were enrolled. When categorised to reflect the maximal worst grade experienced (Grade 0, Grade 1-2 and ≥ Grade 3), the CG reported an increased incidence of severe fatigue (≥ Grade 3) compared with the EG (p = 0.05). No other differences between groups were evident (p > 0.05). ToxT analysis of the four most common toxicities (fatigue, pain, nausea and mood disturbances) demonstrated no difference in the mean grade of each over time (p > 0.05).
CONCLUSIONS: A 10-week exercise intervention reduces the severity of fatigue in AYAs undergoing treatment. While the ToxT approach provided insight into the toxicity profile, adequately powered studies are needed to better understand these differences within a homogenous sample.
BACKGROUND: (ACTRN12620000663954) 10th June 2020.
摘要：
目的：青少年（AYAs）经历了巨大的症状负担，导致癌症治疗相关的毒性（TRT）。证据支持综合锻炼以减轻其他队列中的几种TRT；然而，在AYAs中缺乏证据。TRT的常规报告采用最大等级方法，无法随时间识别轨迹，持久的，或较低等级的毒性。或者，毒性随时间变化的纵向分析(ToxT)可为这些数据提供有临床意义的总结.我们评估了运动干预对接受癌症治疗的AYAs中TRT的纵向影响。
方法：前瞻性，随机试验将参与者分为10周运动干预组(EG)或常规护理对照组(CG).在整个干预过程中收集了有关TRT的详细信息。根据不良事件通用术语标准(CTCAEv5.0)对所有TRT进行分级。
结果：43名参与者（63%为男性，平均年龄21.1岁)。当分类以反映经历的最大最差成绩时(0级、1-2级和≥3级)，与EG相比,CG报告严重疲劳(≥3级)的发生率增加(p=0.05).组间无其他差异(p>0.05)。对四种最常见毒性(疲劳，疼痛,恶心和情绪障碍）显示，随着时间的推移，每个人的平均等级没有差异（p>0.05）。
结论：10周的运动干预降低了接受治疗的AYAs的疲劳严重程度。虽然ToxT方法提供了对毒性概况的洞察，需要足够有力的研究来更好地理解同质样本中的这些差异.
背景：（ACTRN12620000663954）2020年6月10日。
方法：前瞻性，随机试验将参与者分为10周运动干预组(EG)或常规护理对照组(CG).在整个干预过程中收集了有关TRT的详细信息。根据不良事件通用术语标准(CTCAEv5.0)对所有TRT进行分级。
结果：43名参与者（63%为男性，平均年龄21.1岁)。当分类以反映经历的最大最差成绩时(0级、1-2级和≥3级)，与EG相比,CG报告严重疲劳(≥3级)的发生率增加(p=0.05).组间无其他差异(p>0.05)。对四种最常见毒性(疲劳，疼痛,恶心和情绪障碍）显示，随着时间的推移，每个人的平均等级没有差异（p>0.05）。
结论：10周的运动干预降低了接受治疗的AYAs的疲劳严重程度。虽然ToxT方法提供了对毒性概况的洞察，需要足够有力的研究来更好地理解同质样本中的这些差异.
背景：（ACTRN12620000663954）2020年6月10日。
