关键词: (2R,3S)-O-benzoyl isocitrate Ephedra plant kynurenic acid non-ephedrine constituent

Mesh : Ephedrine Ephedra Japan Alkaloids Chromatography, High Pressure Liquid

来  源:   DOI:10.1248/cpb.c24-00043

Abstract:
Ephedra plants, the main components of which are ephedrine alkaloids, are used as traditional medicines in Eastern Asian countries. In this study, we isolated non-ephedrine constituents from various Ephedra plant species cultivated in Japan. HPLC analysis suggested that kynurenic acid and its derivatives accumulated in a wide range of Ephedra plant species. Furthermore, a large amount of (2R,3S)-O-benzoyl isocitrate has been isolated from E. intermedia. This study suggests that Ephedra plants have diverse non-ephedrine constituents.
摘要:
麻黄植物,其主要成分是麻黄碱生物碱,在东亚国家被用作传统药物。在这项研究中,我们从日本种植的各种麻黄植物中分离出非麻黄碱成分。HPLC分析表明犬尿烯酸及其衍生物在多种麻黄植物中积累。此外,大量的(2R,3S)-O-苯甲酰异柠檬酸酯已从中间大肠杆菌中分离出来。这项研究表明,麻黄植物具有多种非麻黄碱成分。
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