%0 Journal Article
%T Comparison of Non-ephedrine Constituents from Ephedra Plants Cultivated in Japan.
%A Hayashi K
%A Miyao Y
%A Matsui H
%A Yamaura T
%A Tanaka K
%A Baba M
%A Hayashi H
%J Chem Pharm Bull (Tokyo)
%V 72
%N 4
%D 2024
%M 38631893
%F 1.903
%R 10.1248/cpb.c24-00043
%X Ephedra plants, the main components of which are ephedrine alkaloids, are used as traditional medicines in Eastern Asian countries. In this study, we isolated non-ephedrine constituents from various Ephedra plant species cultivated in Japan. HPLC analysis suggested that kynurenic acid and its derivatives accumulated in a wide range of Ephedra plant species. Furthermore, a large amount of (2R,3S)-O-benzoyl isocitrate has been isolated from E. intermedia. This study suggests that Ephedra plants have diverse non-ephedrine constituents.