Abstract：
Benzene, toluene, ethylbenzene, and xylene (BTEX) are ubiquitous in the environment, and all of them can cause neurotoxicity. However, the association between BTEX exposure and dyslexia, a disorder with language network-related regions in left hemisphere affected, remains unclear. We aimed to assess the relationship between BTEX exposure and dyslexic odds among school-aged children. A case-control study, including 355 dyslexics and 390 controls from three cities in China, was conducted. Six BTEX metabolites were measured in their urine samples. Logistic regression model was used to explore the association between the BTEX metabolites and the dyslexic odds. Urinary trans,trans-muconic acid (MU: a metabolite of benzene) was significantly associated with an increased dyslexic odds [odds ratio (OR) = 1.23, 95% confidence interval (CI): 1.01, 1.50], and the adjusted OR of the dyslexic odds in the third tertile was 1.72 (95% CI: 1.06, 2.77) compared to that in the lowest tertile regarding urinary MU concentration. Furthermore, the association between urinary MU level and the dyslexic odds was more pronounced among children from low-income families based on stratified analyses. Urinary metabolite levels of toluene, ethylbenzene, and xylene were not found to be associated with the dyslexic odds. In summary, elevated MU concentrations may be associated with an increased dyslexic odds. We should take measures to reduce MU related exposure among children, particularly those with low family income.
摘要：
苯,甲苯,乙苯,二甲苯（BTEX）在环境中无处不在，所有这些都会引起神经毒性。然而,BTEX暴露与阅读障碍之间的联系，左半球语言网络相关区域的疾病受到影响，尚不清楚。我们旨在评估学龄儿童BTEX暴露与阅读障碍几率之间的关系。病例对照研究，包括来自中国三个城市的355个阅读障碍和390个控制，进行了。在其尿液样品中测量了六种BTEX代谢物。使用Logistic回归模型来探索BTEX代谢物与阅读障碍几率之间的关联。尿反式，反式-粘康酸（MU：苯的代谢物）与阅读障碍的几率增加显着相关[优势比（OR）=1.23，95％置信区间（CI）：1.01，1.50]，与最低三位数的尿MU浓度相比，第三三位数的诵读困难几率的校正OR为1.72（95％CI：1.06，2.77）。此外，根据分层分析,低收入家庭儿童的尿MU水平与阅读障碍几率之间的关联更为显著.尿液中甲苯的代谢物水平，乙苯,和二甲苯没有发现与诵读困难的几率有关。总之,MU浓度升高可能与阅读障碍几率增加相关.我们应该采取措施减少儿童与MU相关的暴露，特别是那些家庭收入低的人。
