目的:本研究旨在说明中国女性卵巢储备功能减退的铜状态,尤其是铜的影响,铜蓝蛋白,非铜蓝蛋白结合铜(NCC)和CuZn超氧化物歧化酶(SOD1)。
方法:本病例对照,横断面调查包括卵巢储备减少的女性(DOR组,n=35)和匹配的正常卵巢储备(NOR组,n=35)。血清中的铜水平,铜蓝蛋白,NCC,SOD1促卵泡激素,黄体生成素,雌二醇,睾丸激素,并对抗苗勒管激素进行了检测和分析。
结果:血清铜浓度(60.88%),DOR组NCC(54.75%)和SOD1(54.75%)明显高于NOR组(均P<0.001),在大多数亚组中,三种标记物的浓度较高(P<0.001)。相关性分析验证了铜状态与卵巢功能受损的相关性。此外,线性回归分析显示,NCC和SOD1水平与抗苗勒管激素呈负相关(P<0.05或0.001)。
结论:我们的探索发现铜显著增加,DOR中的NCC和SOD1级别,并建议可能的链接。铜状态有望作为DOR的预测标记。
OBJECTIVE: This study aimed to illustrate the copper status of diminished ovarian reserve in Chinese women, especially the effects of copper, ceruloplasmin, non-ceruloplasmin-bound copper (NCC) and CuZn superoxide dismutase (SOD1).
METHODS: This case-control, cross-sectional investigation included women with diminished ovarian reserve (DOR group, n = 35) and matched normal ovarian reserve (NOR group, n = 35). The serum levels of copper, ceruloplasmin, NCC, SOD1, follicle-stimulating hormone, luteinizing hormone, estradiol, testosterone, and anti-Müllerian hormone were tested and analyzed.
RESULTS: The serum copper concentrations (60.88%), NCC (54.75%) and SOD1 (54.75%) in the DOR group were significantly higher than those in the NOR group (all P < 0.001), and the concentrations of the three markers were higher in most subgroups (P < 0.001). The correlation analysis verified the correlation between copper status and impaired ovarian function. Additionally, linear regression analysis showed that NCC and SOD1 levels were negatively correlated with anti-Müllerian hormone (P < 0.05 or 0.001).
CONCLUSIONS: Our exploration found significant increases in copper, NCC and SOD1 levels in DOR and suggests a possible link. Copper status is expected to serve as the predictive marker for DOR.