PDF(Pubmed)
Abstract：
UNASSIGNED: Acrylamide is a toxic substance formed in some foods that require high-temperature cooking processes and has been implicated as a gonadotoxic agent. Zinc, on the other hand, is a known antioxidant with fertility-enhancing properties. Hence, this study was designed to explore the possible ameliorative effect of zinc in acrylamide-induced gonadotoxicity.
UNASSIGNED: Twenty-four male Wistar rats were randomized into control, acrylamide (10 mg/kg of acrylamide), acrylamide + 1 mg/kg of zinc, and acrylamide + 3 mg/kg of zinc. The administration was via the oral route and lasted for 56 days.
UNASSIGNED: Zinc treatment ameliorated acrylamide-impaired sperm quality, normal testicular histoarchitecture, and hormonal balance, which was accompanied by increased testicular malondialdehyde and interleukin-1β and decreased testicular superoxide dismutase (SOD) and catalase (CAT). Furthermore, zinc prevented acrylamide-induced downregulation of testicular nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and B-cell lymphoma 2 (BCl2) expression and upregulation of testicular nuclear factor kappa B (NF-κB) and bcl-2-like protein 4 (bax) expression.
UNASSIGNED: In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects.
UNASSIGNED: Twenty-four male Wistar rats were randomized into control, acrylamide (10 mg/kg of acrylamide), acrylamide + 1 mg/kg of zinc, and acrylamide + 3 mg/kg of zinc. The administration was via the oral route and lasted for 56 days.
UNASSIGNED: Zinc treatment ameliorated acrylamide-impaired sperm quality, normal testicular histoarchitecture, and hormonal balance, which was accompanied by increased testicular malondialdehyde and interleukin-1β and decreased testicular superoxide dismutase (SOD) and catalase (CAT). Furthermore, zinc prevented acrylamide-induced downregulation of testicular nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and B-cell lymphoma 2 (BCl2) expression and upregulation of testicular nuclear factor kappa B (NF-κB) and bcl-2-like protein 4 (bax) expression.
UNASSIGNED: In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects.
摘要：
■丙烯酰胺是在某些需要高温烹饪过程的食品中形成的有毒物质，并被认为是促性腺激素剂。锌,另一方面,是一种已知的抗氧化剂，具有增强生育力的特性。因此，本研究旨在探讨锌对丙烯酰胺诱导的性腺毒性的可能改善作用。
■将24只雄性Wistar大鼠随机分为对照组，丙烯酰胺（10mg/kg丙烯酰胺），丙烯酰胺+1毫克/千克锌，和丙烯酰胺+3mg/kg锌。通过口服途径给药并持续56天。
■锌治疗改善了丙烯酰胺受损的精子质量，正常的睾丸组织结构，荷尔蒙平衡，伴有睾丸丙二醛和白细胞介素-1β增加，睾丸超氧化物歧化酶（SOD）和过氧化氢酶（CAT）降低。此外，锌可防止丙烯酰胺诱导的睾丸核因子红细胞2相关因子2（Nrf2）的下调，血红素加氧酶-1（HO-1），和B细胞淋巴瘤2（BCl2）的表达和睾丸核因子κB（NF-κB）和bcl-2样蛋白4（bax）的表达上调。
■总而言之，锌可以防止丙烯酰胺引起的睾丸毒性，由其抗氧化剂介导，抗炎,和抗凋亡作用。
■将24只雄性Wistar大鼠随机分为对照组，丙烯酰胺（10mg/kg丙烯酰胺），丙烯酰胺+1毫克/千克锌，和丙烯酰胺+3mg/kg锌。通过口服途径给药并持续56天。
■锌治疗改善了丙烯酰胺受损的精子质量，正常的睾丸组织结构，荷尔蒙平衡，伴有睾丸丙二醛和白细胞介素-1β增加，睾丸超氧化物歧化酶（SOD）和过氧化氢酶（CAT）降低。此外，锌可防止丙烯酰胺诱导的睾丸核因子红细胞2相关因子2（Nrf2）的下调，血红素加氧酶-1（HO-1），和B细胞淋巴瘤2（BCl2）的表达和睾丸核因子κB（NF-κB）和bcl-2样蛋白4（bax）的表达上调。
■总而言之，锌可以防止丙烯酰胺引起的睾丸毒性，由其抗氧化剂介导，抗炎,和抗凋亡作用。
