PDF(Pubmed)
Abstract：
BACKGROUND: Alzheimer\'s disease (AD) is increasing in the Caribbean, especially for persons of African ancestry (PAA) and women. However, studies have mostly utilized surveys without AD biomarkers.
METHODS: In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6), we assessed sex differences and risk factors for serum levels of phosphorylated tau-181 (p-tau181), amyloid-beta (Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL). Blood samples were from 2010 to 2013 for men and from 2019 to 2023 for women.
RESULTS: Women were more obese, hypertensive, and sedentary but reported less smoking and alcohol use than men (age-adjusted p < 0.04). Compared to men, women had worse levels of AD biomarkers, with higher p-tau181 and lower Aβ42/40, independent of covariates (p < 0.001). In sex-stratified analyses, higher p-tau181 was associated with older age in women and with hypertension in men. GFAP and NfL did not differ by sex.
CONCLUSIONS: Women had worse AD biomarkers than men, unexplained by age, cardiometabolic diseases, or lifestyle. Studying risk factors for AD in PAA is warranted, especially for women earlier in life.
METHODS: In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6), we assessed sex differences and risk factors for serum levels of phosphorylated tau-181 (p-tau181), amyloid-beta (Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL). Blood samples were from 2010 to 2013 for men and from 2019 to 2023 for women.
RESULTS: Women were more obese, hypertensive, and sedentary but reported less smoking and alcohol use than men (age-adjusted p < 0.04). Compared to men, women had worse levels of AD biomarkers, with higher p-tau181 and lower Aβ42/40, independent of covariates (p < 0.001). In sex-stratified analyses, higher p-tau181 was associated with older age in women and with hypertension in men. GFAP and NfL did not differ by sex.
CONCLUSIONS: Women had worse AD biomarkers than men, unexplained by age, cardiometabolic diseases, or lifestyle. Studying risk factors for AD in PAA is warranted, especially for women earlier in life.
摘要：
背景：阿尔茨海默病（AD）在加勒比海地区正在增加，特别是非洲血统的人（PAA）和妇女。然而,研究大多利用没有AD生物标志物的调查。
方法：在Tobago健康研究中（n=309；109名妇女，平均年龄70.3±6.6)，我们评估了血清磷酸化tau-181（p-tau181）水平的性别差异和危险因素，淀粉样β（Aβ）42/40比例，胶质纤维酸性蛋白（GFAP），和神经丝轻链(NfL)。男性的血液样本为2010年至2013年，女性的血液样本为2019年至2023年。
结果：女性更肥胖，高血压，久坐不动，但报告吸烟和饮酒少于男性（年龄调整后p<0.04）。和男人相比,女性的AD生物标志物水平更差，p-tau181较高，Aβ42/40较低，与协变量无关（p<0.001）。在性别分层分析中，较高的p-tau181与女性年龄和男性高血压相关.GFAP和NfL没有性别差异。
结论：女性的AD生物标志物比男性差，无法解释的年龄，心脏代谢疾病，或生活方式。有必要研究PAA中AD的危险因素，尤其是对生命早期的女性来说。
方法：在Tobago健康研究中（n=309；109名妇女，平均年龄70.3±6.6)，我们评估了血清磷酸化tau-181（p-tau181）水平的性别差异和危险因素，淀粉样β（Aβ）42/40比例，胶质纤维酸性蛋白（GFAP），和神经丝轻链(NfL)。男性的血液样本为2010年至2013年，女性的血液样本为2019年至2023年。
结果：女性更肥胖，高血压，久坐不动，但报告吸烟和饮酒少于男性（年龄调整后p<0.04）。和男人相比,女性的AD生物标志物水平更差，p-tau181较高，Aβ42/40较低，与协变量无关（p<0.001）。在性别分层分析中，较高的p-tau181与女性年龄和男性高血压相关.GFAP和NfL没有性别差异。
结论：女性的AD生物标志物比男性差，无法解释的年龄，心脏代谢疾病，或生活方式。有必要研究PAA中AD的危险因素，尤其是对生命早期的女性来说。
