{Reference Type}: Journal Article
{Title}: Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health Study.
{Author}: Rosano C;Karikari TK;Cvejkus R;Bellaver B;Ferreira PCL;Zmuda J;Wheeler V;Pascoal TA;Miljkovic I;
{Journal}: Alzheimers Dement (N Y)
{Volume}: 10
{Issue}: 2
{Year}: 2024 Apr-Jun
暂无{DOI}: 10.1002/trc2.12460
{Abstract}: <B>BACKGROUND: </B>Alzheimer's disease (AD) is increasing in the Caribbean, especially for persons of African ancestry (PAA) and women. However, studies have mostly utilized surveys without AD biomarkers.<BR><B>METHODS: </B>In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6), we assessed sex differences and risk factors for serum levels of phosphorylated tau-181 (p-tau181), amyloid-beta (Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL). Blood samples were from 2010 to 2013 for men and from 2019 to 2023 for women.<BR><B>RESULTS: </B>Women were more obese, hypertensive, and sedentary but reported less smoking and alcohol use than men (age-adjusted p < 0.04). Compared to men, women had worse levels of AD biomarkers, with higher p-tau181 and lower Aβ42/40, independent of covariates (p < 0.001). In sex-stratified analyses, higher p-tau181 was associated with older age in women and with hypertension in men. GFAP and NfL did not differ by sex.<BR><B>CONCLUSIONS: </B>Women had worse AD biomarkers than men, unexplained by age, cardiometabolic diseases, or lifestyle. Studying risk factors for AD in PAA is warranted, especially for women earlier in life.