PDF(Pubmed)
Abstract：
Herein, we present the first examples of amino acid decarboxylation via photochemically activated carbonyl sulfide (COS) elimination of the corresponding thioacids. This method offers a mild approach for the decarboxylation of amino acids, furnishing N-alkyl amino derivatives. The methodology was compatible with amino acids displaying both polar and hydrophobic sidechains and was tolerant towards widely used amino acid-protecting groups. The compatibility of the reaction with continuous-flow conditions demonstrates the scalability of the process.
摘要：
在这里，我们介绍了通过光化学活化的羰基硫（COS）消除相应的硫酸的氨基酸脱羧的第一个例子。这种方法为氨基酸的脱羧提供了一种温和的方法，提供N-烷基氨基衍生物。该方法与显示极性和疏水性侧链的氨基酸相容，并且对广泛使用的氨基酸保护基团具有耐受性。反应与连续流动条件的相容性证明了该方法的可扩展性。
