{Reference Type}: Journal Article
{Title}: Radical Mediated Decarboxylation of Amino Acids via Photochemical Carbonyl Sulfide (COS) Elimination.
{Author}: Benny A;Di Simo L;Guazzelli L;Scanlan EM;
{Journal}: Molecules
{Volume}: 29
{Issue}: 7
{Year}: 2024 Mar 25
{Factor}: 4.927
{DOI}: 10.3390/molecules29071465
{Abstract}: Herein, we present the first examples of amino acid decarboxylation via photochemically activated carbonyl sulfide (COS) elimination of the corresponding thioacids. This method offers a mild approach for the decarboxylation of amino acids, furnishing N-alkyl amino derivatives. The methodology was compatible with amino acids displaying both polar and hydrophobic sidechains and was tolerant towards widely used amino acid-protecting groups. The compatibility of the reaction with continuous-flow conditions demonstrates the scalability of the process.