%0 Journal Article
%T Radical Mediated Decarboxylation of Amino Acids via Photochemical Carbonyl Sulfide (COS) Elimination.
%A Benny A
%A Di Simo L
%A Guazzelli L
%A Scanlan EM
%J Molecules
%V 29
%N 7
%D 2024 Mar 25
%M 38611745
%F 4.927
%R 10.3390/molecules29071465
%X Herein, we present the first examples of amino acid decarboxylation via photochemically activated carbonyl sulfide (COS) elimination of the corresponding thioacids. This method offers a mild approach for the decarboxylation of amino acids, furnishing N-alkyl amino derivatives. The methodology was compatible with amino acids displaying both polar and hydrophobic sidechains and was tolerant towards widely used amino acid-protecting groups. The compatibility of the reaction with continuous-flow conditions demonstrates the scalability of the process.