Abstract：
Bile Salts (BS) are responsible for stimulating lipid digestion in our organism. Gut microbiota are responsible for the deconjugation process of primary conjugated to secondary unconjugated BS. We use two structurally distinct BS and characterize the rate of lipolysis as a compound parameter. A static in-vitro digestion model as well as meta-analysis of literature data has been performed to determine the most influential factors affecting the lipid digestion process. The results demonstrate that lipolysis of emulsions using conjugated BS (NaTC, FFA = 60.0 %, CMC in SIF = 5.58 mM, MSR of linoleic acid = 0.21, rate of adsorption = -0.057 mN/m.s) enhances the release of FFA compared to deconjugated BS (NaDC, FFA = 49.5 %, CMC in SIF = 2.49 mM, MSR of linoleic acid = 0.16 rate of adsorption = -0.064 mN/m.s). These results indicate that conjugation plays an important role in controlling the rate of lipolysis in our organism which can be in turn, tuned by the microflora composition of our gut, ultimately controlling the rate of deconjugation of the BS.
摘要：
胆汁盐（BS）负责刺激我们生物体中的脂质消化。肠道微生物群负责初级缀合与次级未缀合BS的解缀合过程。我们使用两个结构上不同的BS，并将脂解速率表征为复合参数。已经进行了静态体外消化模型以及文献数据的荟萃分析，以确定影响脂质消化过程的最有影响的因素。结果表明，使用共轭BS（NaTC，FFA=60.0%，CMC在SIF=5.58mM，亚油酸的MSR=0.21,吸附率=-0.057mN/m。s)与去共轭BS(NaDC，FFA=49.5%，CMC在SIF=2.49mM，亚油酸的MSR=0.16吸附率=-0.064mN/m。s).这些结果表明，共轭在控制我们生物体的脂解速率中起着重要作用，根据我们肠道的微生物组成，最终控制BS的解共轭率。
