PDF(Pubmed)
Abstract：
Introduction: Most recent clinical reports from the American Academy of Pediatrics (AAP) concluded current evidence does not support routine universal administration of probiotics to preterm infants, particularly those with birth weight <1000 grams. Despite this, the use of probiotics is increasing in US neonatal intensive care units (NICU).Objectives: Collaborating with the Perinatal Neonatal Medicine of AAP, we conducted a national survey to obtain neonatologist opinion on probiotics use.Methods: Survey questionnaires were sent to 3000 neonatologists via email.Results: Of 3000 potential respondents, 249 (8.3 %) completed the survey. Seventy-five (30%) neonatologists working in 23 different NICUs reported using probiotics in their practice, while 168 (70%) neonatologists working in 54 different NICUs reported not using probiotics. Of those not currently use probiotics, 49% indicated they would consider using probiotics in the future vs. 12% indicating they would not use probiotics. The most common indication for probiotics use was average gestational age < 32 weeks and mean birth weight < 1500 grams. Probiotics were discontinued at mean gestational age of 35 weeks. Respondents who prescribe probiotics were more likely to work in a setting without fellowship or residency training (48% vs 20%). Probiotics users were more often from the West (29 % vs 7%) and less often from Northeast (5% vs 34%) compared to non-users. The proportion of those using probiotics did not significantly differ by NICU size, NICU level, or years working in a NICU. Similac Tri-Blend, Evivo, and Culturelle were the top three probiotics used in the respondent\'s NICU.Conclusion: Though a majority of respondents are not currently using probiotics in their NICU, a large number of nonusers are interested in using probiotics in the future. Differences continue to exist in the brand of probiotics used in US NICUs.
摘要：
简介：美国儿科学会（AAP）的最新临床报告得出的结论是，目前的证据不支持对早产儿常规普遍施用益生菌。特别是那些出生体重<1000克的人。尽管如此,美国新生儿重症监护病房(NICU)中益生菌的使用正在增加.目标：与AAP的围产期新生儿医学合作，我们进行了一项全国调查，以获得新生儿学家对益生菌使用的意见。方法：通过电子邮件向3000名新生儿科医师发送调查问卷。结果：在3000名潜在受访者中，249（8.3％）完成了调查。在23个不同的NICU工作的75名（30％）新生儿学家报告说，他们在实践中使用了益生菌，而在54个不同的NICU工作的168名（70％）新生儿学家报告没有使用益生菌。在那些目前不使用益生菌的人中，49%的人表示他们会考虑在未来使用益生菌，而不是12%的人表示他们不会使用益生菌。使用益生菌最常见的适应症是平均胎龄<32周，平均出生体重<1500克。在平均胎龄为35周时停用益生菌。开益生菌处方的受访者更有可能在没有团契或住院医师培训的环境中工作(48%对20%)。与非使用者相比，益生菌使用者更经常来自西方（29％对7％），而较少来自东北（5％对34％）。使用益生菌的比例因NICU大小而没有显着差异，NICU级别,或在NICU工作多年。SimilacTri-Blend,Evolve,和Culturelle是受访者NICU中使用的三大益生菌。结论：尽管大多数受访者目前并未在其NICU中使用益生菌，大量非使用者对将来使用益生菌感兴趣.美国NICU中使用的益生菌品牌继续存在差异。
