Abstract：
OBJECTIVE: Recently, the ILAE Nosology and Definitions Task Force defined diagnostic criteria for epilepsy syndromes. There is paucity of data on the use of these new diagnostic criteria in children with epilepsy, and how these criteria may lead to changes from previous practice.
METHODS: This was a retrospective chart review of data of children attending the epilepsy clinic in a tertiary care children\'s hospital from January 2011 to January 2023. The clinical details such as age at onset, types of seizures, co-morbidities, and results of EEG, MRI and genetic testing were reviewed. Epilepsy syndrome diagnosis was made as per the ILAE 2022 criteria, and compared with the previous syndrome diagnosis as per records.
RESULTS: Data from 1550 children (63 % boys) with epilepsy were analysed, and 55.4 % children were classified to have epilepsy syndromes as per the new ILAE 2022 diagnostic criteria. Application of the new 2022 ILAE diagnostic criteria was associated with a change in name alone in 676 (77.8 %) children. Hundred (11.5 %) children were newly classified under an epilepsy syndrome who had previously remained unclassified. Eleven (1.3 %) children who were previously classified into an epilepsy syndrome could not be classified using the new diagnostic criteria. Eight (0.9 %) were shifted to a new syndromic category. Overall, change in diagnosis occurred in 13.7 (11.5 + 1.3 + 0.9)%. No change in epilepsy syndrome classification/nomenclature occurred in 74 (8.5 %) children.
CONCLUSIONS: The new diagnostic criteria led to an overall change in diagnosis in 13.7 % of children with epilepsy. These criteria will hopefully lead to uniformity in diagnosis of epilepsy syndromes across diverse settings.
METHODS: This was a retrospective chart review of data of children attending the epilepsy clinic in a tertiary care children\'s hospital from January 2011 to January 2023. The clinical details such as age at onset, types of seizures, co-morbidities, and results of EEG, MRI and genetic testing were reviewed. Epilepsy syndrome diagnosis was made as per the ILAE 2022 criteria, and compared with the previous syndrome diagnosis as per records.
RESULTS: Data from 1550 children (63 % boys) with epilepsy were analysed, and 55.4 % children were classified to have epilepsy syndromes as per the new ILAE 2022 diagnostic criteria. Application of the new 2022 ILAE diagnostic criteria was associated with a change in name alone in 676 (77.8 %) children. Hundred (11.5 %) children were newly classified under an epilepsy syndrome who had previously remained unclassified. Eleven (1.3 %) children who were previously classified into an epilepsy syndrome could not be classified using the new diagnostic criteria. Eight (0.9 %) were shifted to a new syndromic category. Overall, change in diagnosis occurred in 13.7 (11.5 + 1.3 + 0.9)%. No change in epilepsy syndrome classification/nomenclature occurred in 74 (8.5 %) children.
CONCLUSIONS: The new diagnostic criteria led to an overall change in diagnosis in 13.7 % of children with epilepsy. These criteria will hopefully lead to uniformity in diagnosis of epilepsy syndromes across diverse settings.
摘要：
目标：最近，ILAE病例学和定义工作组定义了癫痫综合征的诊断标准。关于在癫痫儿童中使用这些新的诊断标准的数据很少，以及这些标准如何导致以前的实践发生变化。
方法：这是2011年1月至2023年1月在三级保健儿童医院就诊癫痫门诊的儿童数据的回顾性图表回顾。临床细节，如发病年龄，癫痫发作的类型,合并症,和脑电图的结果，对MRI和基因检测进行了综述。按照ILAE2022标准进行癫痫综合征诊断，并根据记录与以前的综合征诊断进行比较。
结果：分析了1550名癫痫儿童（63%为男孩）的数据，根据新的ILAE2022诊断标准,55.4%的儿童被归类为癫痫综合征.新的2022年ILAE诊断标准的应用与676名（77.8％）儿童的姓名变更有关。100名（11.5％）儿童被新归类为癫痫综合征，以前未分类。先前被归类为癫痫综合征的11名（1.3％）儿童无法使用新的诊断标准进行分类。八个（0.9％）被转移到新的综合征类别。总的来说,诊断改变发生在13.7(11.5+1.3+0.9)%。74名（8.5％）儿童的癫痫综合征分类/命名没有变化。
结论：新的诊断标准导致13.7%的癫痫患儿的诊断发生整体变化。这些标准有望导致不同环境中癫痫综合征的诊断均匀性。
方法：这是2011年1月至2023年1月在三级保健儿童医院就诊癫痫门诊的儿童数据的回顾性图表回顾。临床细节，如发病年龄，癫痫发作的类型,合并症,和脑电图的结果，对MRI和基因检测进行了综述。按照ILAE2022标准进行癫痫综合征诊断，并根据记录与以前的综合征诊断进行比较。
结果：分析了1550名癫痫儿童（63%为男孩）的数据，根据新的ILAE2022诊断标准,55.4%的儿童被归类为癫痫综合征.新的2022年ILAE诊断标准的应用与676名（77.8％）儿童的姓名变更有关。100名（11.5％）儿童被新归类为癫痫综合征，以前未分类。先前被归类为癫痫综合征的11名（1.3％）儿童无法使用新的诊断标准进行分类。八个（0.9％）被转移到新的综合征类别。总的来说,诊断改变发生在13.7(11.5+1.3+0.9)%。74名（8.5％）儿童的癫痫综合征分类/命名没有变化。
结论：新的诊断标准导致13.7%的癫痫患儿的诊断发生整体变化。这些标准有望导致不同环境中癫痫综合征的诊断均匀性。
