Abstract：
BACKGROUND: Pilomatrixoma is a benign skin neoplasm that is common in children and is often misdiagnosed. This study aimed to summarize the clinical and pathological features of pilomatrixoma in children.
METHODS: Data on demographic information, clinical and pathological features, diagnosis, and treatment of 171 patients with pilomatrixoma from Shenzhen Baoan Women\'s and Children\'s Hospital were collected and analyzed retrospectively.
RESULTS: The mean age of the patients was 5.7 (standard deviation [SD] = 3.9) years old, and there were 2 age peaks (≤1 year old, 5-11 years old) and 2 age valleys (2-4 years old, ≥12 years old). The mean disease course was 9.3 (SD = 14.1) months, 69.0%, 86.5%, and 95.3% of the patients\' disease course in 6 months, 12 months, and 24 months, respectively. The mean tumor volume was 0.6 (SD = 1.0) cm3, and 81.3% of the patients\' tumor volume ≤1.0 cm3. Tumors were distributed sequentially in the head and neck (77.2%), upper limbs (12.9%), trunk (7.6%), and lower limbs (2.3%). The correct rates of clinical and ultrasonic diagnosis were 50.9% and 38.6%, respectively. The two most common pathological features of pilomatrixoma were shadow cells (99.4%) and basaloid cells (94.7%). There were no significant differences in age, disease course, or tumor volume between the male and female patients (p > 0.05). The age and tumor volume of the patients in different body parts were significantly different (P1 = 3.10E-05 and P2 = 5.60E-05, respectively). The correlation between the disease course and tumor volume was positively significant (p ≤ 0.05). There was a significant correlation between the disease course and tumor volume in patients with tumors at upper limbs (p = 0.03).
CONCLUSIONS: The age of children with pilomatrixoma presented 2 peaks and 2 valleys. Most patients had disease courses in 24 months and with tumor volumes ≤1.0 cm3. The correct rates of clinical and ultrasonic diagnosis were relatively low. The head and neck were the most common distribution sites of pilomatrixoma, and shadow cells and basaloid cells were the most common pathological features. The tumor volume was positively correlated with disease course in patients with pilomatrixoma.
METHODS: Data on demographic information, clinical and pathological features, diagnosis, and treatment of 171 patients with pilomatrixoma from Shenzhen Baoan Women\'s and Children\'s Hospital were collected and analyzed retrospectively.
RESULTS: The mean age of the patients was 5.7 (standard deviation [SD] = 3.9) years old, and there were 2 age peaks (≤1 year old, 5-11 years old) and 2 age valleys (2-4 years old, ≥12 years old). The mean disease course was 9.3 (SD = 14.1) months, 69.0%, 86.5%, and 95.3% of the patients\' disease course in 6 months, 12 months, and 24 months, respectively. The mean tumor volume was 0.6 (SD = 1.0) cm3, and 81.3% of the patients\' tumor volume ≤1.0 cm3. Tumors were distributed sequentially in the head and neck (77.2%), upper limbs (12.9%), trunk (7.6%), and lower limbs (2.3%). The correct rates of clinical and ultrasonic diagnosis were 50.9% and 38.6%, respectively. The two most common pathological features of pilomatrixoma were shadow cells (99.4%) and basaloid cells (94.7%). There were no significant differences in age, disease course, or tumor volume between the male and female patients (p > 0.05). The age and tumor volume of the patients in different body parts were significantly different (P1 = 3.10E-05 and P2 = 5.60E-05, respectively). The correlation between the disease course and tumor volume was positively significant (p ≤ 0.05). There was a significant correlation between the disease course and tumor volume in patients with tumors at upper limbs (p = 0.03).
CONCLUSIONS: The age of children with pilomatrixoma presented 2 peaks and 2 valleys. Most patients had disease courses in 24 months and with tumor volumes ≤1.0 cm3. The correct rates of clinical and ultrasonic diagnosis were relatively low. The head and neck were the most common distribution sites of pilomatrixoma, and shadow cells and basaloid cells were the most common pathological features. The tumor volume was positively correlated with disease course in patients with pilomatrixoma.
摘要：
简介Pilomatrixoma是一种良性皮肤肿瘤，常见于儿童，常被误诊。本研究旨在总结儿童毛曲菌瘤的临床和病理特征。方法人口统计信息数据，临床和病理特征，诊断,收集深圳市宝安妇女儿童医院收治的171例毛心房瘤患者，并对其治疗进行回顾性分析。结果患者平均年龄为5.7岁(标准差(SD)=3.9),有两个年龄高峰(≤1岁，5-11岁）和两个年龄谷（2-4岁，≥12岁)。平均病程为9.3(SD=14.1)个月，69.0%,86.5%,95.3%的患者病程在6个月内，12个月,还有24个月,分别。平均肿瘤体积为0.6(SD=1.0)cm3，81.3%的患者肿瘤体积≤1.0cm3。肿瘤依次分布于头颈部(77.2%),上肢(12.9%),树干(7.6%),和下肢(2.3%)。临床和超声诊断正确率分别为50.9%和38.6%,分别。毛囊瘤最常见的两种病理特征是阴影细胞（99.4％）和基底细胞（94.7％）。在年龄上没有显著差异,病程,或肿瘤体积在男性和女性患者之间(P>0.05)。不同部位患者的年龄和肿瘤体积差异有统计学意义(P1=3.10E-05和P2=5.60E-05)。病程与肿瘤体积呈正相关(P≤0.05)。上肢肿瘤患者的病程与肿瘤体积之间存在显着相关性（P=0.03）。结论毛心房腺瘤患儿的年龄呈两峰两谷。大多数患者的病程为24个月，肿瘤体积≤1.0cm3。临床和超声诊断的正确率相对较低。头颈部是最常见的毛房瘤分布部位,阴影细胞和基底细胞是最常见的病理特征。毛曲菌瘤患者的肿瘤体积与病程呈正相关。
