PDF(Pubmed)
Abstract：
Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC50 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.
摘要：
使用基于高含量成像的中和试验评估流感病毒的抗病毒易感性。帽依赖性核酸内切酶抑制剂，baloxavir和AV5116，优于AV5115对A型病毒，AV5116对测试的PA突变体最有效。然而,这三种抑制剂对来自6个谱系的C型病毒显示出相当的活性(EC508-22nM)。香蕉凝集素和单克隆抗体，YA3，靶向血凝素酯酶蛋白有效中和一些，但不是全部,C型病毒。
