%0 Journal Article
%T Influenza C virus susceptibility to antivirals with different mechanisms of action.
%A Chesnokov A
%A Ivashchenko AA
%A Matsuzaki Y
%A Takashita E
%A Mishin VP
%A Ivachtchenko AV
%A Gubareva LV
%J Antimicrob Agents Chemother
%V 68
%N 5
%D 2024 May 2
%M 38587392
%F 5.938
%R 10.1128/aac.01727-23
%X Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC50 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.