{Reference Type}: Journal Article
{Title}: Influenza C virus susceptibility to antivirals with different mechanisms of action.
{Author}: Chesnokov A;Ivashchenko AA;Matsuzaki Y;Takashita E;Mishin VP;Ivachtchenko AV;Gubareva LV;
{Journal}: Antimicrob Agents Chemother
{Volume}: 68
{Issue}: 5
{Year}: 2024 May 2
{Factor}: 5.938
{DOI}: 10.1128/aac.01727-23
{Abstract}: Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC50 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.