Abstract：
UNASSIGNED: Cognitive impairment (CI) in older individuals has a high morbidity rate worldwide, with poor diagnostic methods and susceptible population identification. This study aimed to investigate the relationship between different retinal metrics and CI in a particular population, emphasizing polyvascular status.
UNASSIGNED: We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers, retinal nerve fiber layer (RNFL) thickness, and cognitive function of 3,785 participants, aged 40 years or older. Logistic regression was used to analyze the relationship between retinal metrics and cognitive function. Subgroups stratified by different vascular statuses were also analyzed.
UNASSIGNED: RNFL thickness was significantly thinner in the CI group (odds ratio: 0.973, 95% confidence interval: 0.953-0.994). In the subgroup analysis, the difference still existed in the non-intracranial arterial stenosis, non-extracranial carotid arterial stenosis, and peripheral arterial disease subgroups ( P < 0.05).
UNASSIGNED: A thin RNFL is associated with CI, especially in people with non-large vessel stenosis. The underlying small vessel change in RNFL and CI should be investigated in the future.
UNASSIGNED: We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers, retinal nerve fiber layer (RNFL) thickness, and cognitive function of 3,785 participants, aged 40 years or older. Logistic regression was used to analyze the relationship between retinal metrics and cognitive function. Subgroups stratified by different vascular statuses were also analyzed.
UNASSIGNED: RNFL thickness was significantly thinner in the CI group (odds ratio: 0.973, 95% confidence interval: 0.953-0.994). In the subgroup analysis, the difference still existed in the non-intracranial arterial stenosis, non-extracranial carotid arterial stenosis, and peripheral arterial disease subgroups ( P < 0.05).
UNASSIGNED: A thin RNFL is associated with CI, especially in people with non-large vessel stenosis. The underlying small vessel change in RNFL and CI should be investigated in the future.
摘要：
■老年人的认知障碍（CI）在全球范围内具有很高的发病率，诊断方法差，易感人群识别。本研究旨在调查特定人群中不同视网膜指标与CI之间的关系，强调多血管状态。
■我们从视网膜血管口径的无症状多血管异常社区研究中收集了信息，视网膜神经纤维层（RNFL）厚度，和3,785名参与者的认知功能，40岁或以上。采用Logistic回归分析视网膜指标与认知功能的关系。还分析了按不同血管状态分层的亚组。
■CI组RNFL厚度明显变薄（比值比：0.973，95%置信区间：0.953-0.994）。在亚组分析中，在非颅内动脉狭窄中仍然存在差异，非颅外颈动脉狭窄,和外周动脉疾病亚组(P<0.05)。
■薄RNFL与CI相关，尤其是在非大血管狭窄患者中。未来应研究RNFL和CI中潜在的小血管变化。
■我们从视网膜血管口径的无症状多血管异常社区研究中收集了信息，视网膜神经纤维层（RNFL）厚度，和3,785名参与者的认知功能，40岁或以上。采用Logistic回归分析视网膜指标与认知功能的关系。还分析了按不同血管状态分层的亚组。
■CI组RNFL厚度明显变薄（比值比：0.973，95%置信区间：0.953-0.994）。在亚组分析中，在非颅内动脉狭窄中仍然存在差异，非颅外颈动脉狭窄,和外周动脉疾病亚组(P<0.05)。
■薄RNFL与CI相关，尤其是在非大血管狭窄患者中。未来应研究RNFL和CI中潜在的小血管变化。
