METHODS: The medical records of consecutive patients who were hospitalized with AE-fIIP from January 2008 to December 2019 were analyzed for the incidence, causative pathogen, and survival of HAP. The records of patients with an obvious infection-triggered AE were excluded from analysis.
RESULTS: There were 128 patients with AE-fIIP (89 with idiopathic pulmonary fibrosis [IPF] and 39 with non-IPF fIIP) who were hospitalized a total of 155 times (111 with IPF and 44 with non-IPF fIIP). HAP occurred in 49 patients (40 with IPF and 9 with non-IPF fIIP). The incidence and the in-hospital mortality rates of HAP in patients with AE-fIIP were high, at 32.2% and 48.9%, respectively. Corynebacterium spp. was the most common causative pathogen, which was followed by human cytomegalovirus (HCMV).
CONCLUSIONS: The incidence and the in-hospital mortality rates of HAP in patients with AE-fIIP are high. To improve their survival, patients with fIIP who had AEs and HAP should receive prompt empirical treatment for possible infections with Corynebacterium spp. and testing for HCMV.
方法:对2008年1月至2019年12月连续住院AE-fIIP患者的病历进行发病率分析。致病病原体,和HAP的生存。从分析中排除具有明显感染触发的AE的患者的记录。
结果:128例AE-fIIP患者(89例特发性肺纤维化[IPF]和39例非IPFfIIP)共住院155次(111例IPF和44例非IPFfIIP)。49例患者发生HAP(40例IPF和9例非IPFfIIP)。AE-fIIP患者的HAP发病率和院内死亡率较高,分别为32.2%和48.9%,分别。棒状杆菌属。是最常见的病原体,其次是人巨细胞病毒(HCMV)。
结论:AE-fIIP患者的HAP发病率和院内死亡率较高。为了改善他们的生存,有AE和HAP的fIIP患者,对于可能的棒状杆菌属感染,应及时接受经验性治疗.和HCMV测试。