PDF(Pubmed)
Abstract：
Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders. This narrative review aims to explore the role of TIM-3 in sepsis and evaluate its potential as a promising target for immunotherapy. We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune responses. Furthermore, we examine the preclinical studies investigating the regulation of TIM-3 signaling pathways in septic models, highlighting the potential therapeutic benefits and challenges associated with targeting TIM-3. Overall, this review emphasizes the importance of TIM-3 in sepsis pathogenesis and underscores the promising prospects of TIM-3-based immunotherapy as a potential strategy to combat this life-threatening condition.
摘要：
脓毒症仍然是全球死亡率和发病率的重要原因。有效的治疗选择有限。T细胞免疫球蛋白和含粘蛋白结构域的分子3（TIM-3）已成为各种免疫相关疾病中的潜在治疗靶标。这篇叙述性综述旨在探讨TIM-3在脓毒症中的作用，并评估其作为有希望的免疫治疗靶标的潜力。我们讨论了脓毒症期间TIM-3的动态表达模式及其在调节免疫反应中的作用。此外，我们检查了研究脓毒症模型中TIM-3信号通路调节的临床前研究，强调与靶向TIM-3相关的潜在治疗益处和挑战。总的来说,这篇综述强调了TIM-3在脓毒症发病机制中的重要性,并强调了以TIM-3为基础的免疫治疗作为对抗这一危及生命的潜在策略的前景.
