{Reference Type}: Journal Article {Title}: The role of TIM-3 in sepsis: a promising target for immunotherapy? {Author}: Wang C;Liu J;Wu Q;Wang Z;Hu B;Bo L; {Journal}: Front Immunol {Volume}: 15 {Issue}: 0 {Year}: 2024 {Factor}: 8.786 {DOI}: 10.3389/fimmu.2024.1328667 {Abstract}: Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders. This narrative review aims to explore the role of TIM-3 in sepsis and evaluate its potential as a promising target for immunotherapy. We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune responses. Furthermore, we examine the preclinical studies investigating the regulation of TIM-3 signaling pathways in septic models, highlighting the potential therapeutic benefits and challenges associated with targeting TIM-3. Overall, this review emphasizes the importance of TIM-3 in sepsis pathogenesis and underscores the promising prospects of TIM-3-based immunotherapy as a potential strategy to combat this life-threatening condition.