%0 Journal Article
%T The role of TIM-3 in sepsis: a promising target for immunotherapy?
%A Wang C
%A Liu J
%A Wu Q
%A Wang Z
%A Hu B
%A Bo L
%J Front Immunol
%V 15
%N 0
%D 2024
%M 38576606
%F 8.786
%R 10.3389/fimmu.2024.1328667
%X Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders. This narrative review aims to explore the role of TIM-3 in sepsis and evaluate its potential as a promising target for immunotherapy. We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune responses. Furthermore, we examine the preclinical studies investigating the regulation of TIM-3 signaling pathways in septic models, highlighting the potential therapeutic benefits and challenges associated with targeting TIM-3. Overall, this review emphasizes the importance of TIM-3 in sepsis pathogenesis and underscores the promising prospects of TIM-3-based immunotherapy as a potential strategy to combat this life-threatening condition.